NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20888-5 |
| _version_ | 1818425473084948480 |
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| author | Yuli He Huayue Song Jian Chen Shaolin Zhu |
| author_facet | Yuli He Huayue Song Jian Chen Shaolin Zhu |
| author_sort | Yuli He |
| collection | DOAJ |
| description | Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines. |
| first_indexed | 2024-12-14T14:14:29Z |
| format | Article |
| id | doaj.art-21aec21fa86f4c61be72924901c3cf28 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:14:29Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-21aec21fa86f4c61be72924901c3cf282022-12-21T22:58:13ZengNature PortfolioNature Communications2041-17232021-01-011211710.1038/s41467-020-20888-5NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylaminesYuli He0Huayue Song1Jian Chen2Shaolin Zhu3State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing UniversityChiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines.https://doi.org/10.1038/s41467-020-20888-5 |
| spellingShingle | Yuli He Huayue Song Jian Chen Shaolin Zhu NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines Nature Communications |
| title | NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines |
| title_full | NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines |
| title_fullStr | NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines |
| title_full_unstemmed | NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines |
| title_short | NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines |
| title_sort | nih catalyzed asymmetric hydroarylation of n acyl enamines to chiral benzylamines |
| url | https://doi.org/10.1038/s41467-020-20888-5 |
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