Efficacy of Global Leadership Initiative on Malnutrition as potential cachexia screening tool for patients with solid cancer
Abstract Purpose Cachexia has a very high prevalence in patients with cancer, and lacks effective screening tools yet. Global Leadership Initiative on Malnutrition (GLIM) is a novel malnutrition assessment tool, with increased important roles in malnutrition diagnosis for patients with cancer. Howev...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
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| Series: | Nutrition Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12937-022-00829-2 |
| _version_ | 1811188195957669888 |
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| author | Mengmeng Song Qi Zhang Tong Liu Meng Tang Xi Zhang Guotian Ruan Xiaowei Zhang Kangping Zhang Yizhong Ge Ming Yang Wei Li Minghua Cong Kunhua Wang Chunhua Song Hanping Shi |
| author_facet | Mengmeng Song Qi Zhang Tong Liu Meng Tang Xi Zhang Guotian Ruan Xiaowei Zhang Kangping Zhang Yizhong Ge Ming Yang Wei Li Minghua Cong Kunhua Wang Chunhua Song Hanping Shi |
| author_sort | Mengmeng Song |
| collection | DOAJ |
| description | Abstract Purpose Cachexia has a very high prevalence in patients with cancer, and lacks effective screening tools yet. Global Leadership Initiative on Malnutrition (GLIM) is a novel malnutrition assessment tool, with increased important roles in malnutrition diagnosis for patients with cancer. However, whether GLIM can be used as an effective screening tool remains unknown. Methods We performed a multicenter cohort study including 8,478 solid tumor patients from 40 clinical centers throughout China. Cachexia was diagnosed based on the 2011 international cancer cachexia consensus. The receiver operating characteristic curves (ROC) and decision curve analysis (DCA) were developed to determine the efficacy and clinical net benefit of GLIM and Patient-Generated Subjective Global Assessment (PG-SGA) in the detection of cancer cachexia, respectively. Results According to the consensus guidelines, 1,441 (17.0%) cancer patients were diagnosed with cachexia among 8,478 patients in the present study. The sensitivity of one-step GLIM and two-step GLIM for detecting cachexia were 100 and 88.8%, respectively, while that of PG-SGA was 86.2%. The accuracies of one-step GLIM and two-step GLIM reached 67.4 and 91.3%, which were higher than that of PG-SGA (63.1%). The area under the curves (AUCs) of one-step GLIM (0.835) and two-step GLIM (0.910) were higher than PG-SGA (0.778) in patients with cancer. The DCA also revealed that two-step GLIM had better clinical effect than PG-SGA between 20-50% threshold probabilities. Conclusion GLIM could be used as an effective tool in screening cancer cachexia, two-step GLIM criteria show more accurate while one-step GLIM criteria is more sensitive. Trial registration ChiCTR1800020329. |
| first_indexed | 2024-04-11T14:16:26Z |
| format | Article |
| id | doaj.art-21afd70706ac4281b5b0aa62bbef32d0 |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-04-11T14:16:26Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-21afd70706ac4281b5b0aa62bbef32d02022-12-22T04:19:24ZengBMCNutrition Journal1475-28912022-12-012111910.1186/s12937-022-00829-2Efficacy of Global Leadership Initiative on Malnutrition as potential cachexia screening tool for patients with solid cancerMengmeng Song0Qi Zhang1Tong Liu2Meng Tang3Xi Zhang4Guotian Ruan5Xiaowei Zhang6Kangping Zhang7Yizhong Ge8Ming Yang9Wei Li10Minghua Cong11Kunhua Wang12Chunhua Song13Hanping Shi14Department of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalCancer Center of the First Hospital of Jilin UniversityDepartment of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeYunnan UniversityDepartment of Epidemiology and Statistics, Henan Key Laboratory of Tumor Epidemiology College of Public Health, Zhengzhou UniversityDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan HospitalAbstract Purpose Cachexia has a very high prevalence in patients with cancer, and lacks effective screening tools yet. Global Leadership Initiative on Malnutrition (GLIM) is a novel malnutrition assessment tool, with increased important roles in malnutrition diagnosis for patients with cancer. However, whether GLIM can be used as an effective screening tool remains unknown. Methods We performed a multicenter cohort study including 8,478 solid tumor patients from 40 clinical centers throughout China. Cachexia was diagnosed based on the 2011 international cancer cachexia consensus. The receiver operating characteristic curves (ROC) and decision curve analysis (DCA) were developed to determine the efficacy and clinical net benefit of GLIM and Patient-Generated Subjective Global Assessment (PG-SGA) in the detection of cancer cachexia, respectively. Results According to the consensus guidelines, 1,441 (17.0%) cancer patients were diagnosed with cachexia among 8,478 patients in the present study. The sensitivity of one-step GLIM and two-step GLIM for detecting cachexia were 100 and 88.8%, respectively, while that of PG-SGA was 86.2%. The accuracies of one-step GLIM and two-step GLIM reached 67.4 and 91.3%, which were higher than that of PG-SGA (63.1%). The area under the curves (AUCs) of one-step GLIM (0.835) and two-step GLIM (0.910) were higher than PG-SGA (0.778) in patients with cancer. The DCA also revealed that two-step GLIM had better clinical effect than PG-SGA between 20-50% threshold probabilities. Conclusion GLIM could be used as an effective tool in screening cancer cachexia, two-step GLIM criteria show more accurate while one-step GLIM criteria is more sensitive. Trial registration ChiCTR1800020329.https://doi.org/10.1186/s12937-022-00829-2CancerCachexiaGLIMPG-SGAScreening tools |
| spellingShingle | Mengmeng Song Qi Zhang Tong Liu Meng Tang Xi Zhang Guotian Ruan Xiaowei Zhang Kangping Zhang Yizhong Ge Ming Yang Wei Li Minghua Cong Kunhua Wang Chunhua Song Hanping Shi Efficacy of Global Leadership Initiative on Malnutrition as potential cachexia screening tool for patients with solid cancer Nutrition Journal Cancer Cachexia GLIM PG-SGA Screening tools |
| title | Efficacy of Global Leadership Initiative on Malnutrition as potential cachexia screening tool for patients with solid cancer |
| title_full | Efficacy of Global Leadership Initiative on Malnutrition as potential cachexia screening tool for patients with solid cancer |
| title_fullStr | Efficacy of Global Leadership Initiative on Malnutrition as potential cachexia screening tool for patients with solid cancer |
| title_full_unstemmed | Efficacy of Global Leadership Initiative on Malnutrition as potential cachexia screening tool for patients with solid cancer |
| title_short | Efficacy of Global Leadership Initiative on Malnutrition as potential cachexia screening tool for patients with solid cancer |
| title_sort | efficacy of global leadership initiative on malnutrition as potential cachexia screening tool for patients with solid cancer |
| topic | Cancer Cachexia GLIM PG-SGA Screening tools |
| url | https://doi.org/10.1186/s12937-022-00829-2 |
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