Analysis of risk factors for pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii
Objective To analyze clinical characteristics and risk factors of pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii （XDRAB）， evaluate antimicrobial therapy and prognosis of XDRAB patients， aiming to provide references for effective prevention and control of nosocomial...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of New Medicine
2023-02-01
|
| Series: | Xin yixue |
| Subjects: | |
| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1677813357707-58493010.pdf |
| _version_ | 1811160856373755904 |
|---|---|
| author | Bai Xuejiao, Hu Xuejiao, Zhao Yue, Yang Lihui, Ling Yong |
| author_facet | Bai Xuejiao, Hu Xuejiao, Zhao Yue, Yang Lihui, Ling Yong |
| author_sort | Bai Xuejiao, Hu Xuejiao, Zhao Yue, Yang Lihui, Ling Yong |
| collection | DOAJ |
| description | Objective To analyze clinical characteristics and risk factors of pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii （XDRAB）， evaluate antimicrobial therapy and prognosis of XDRAB patients， aiming to provide references for effective prevention and control of nosocomial infection and clinical diagnosis and treatment. Methods Patients with XDRAB isolated from the lower respiratory tract specimens were collected. The number of repeated cases and colonization strains were excluded. The case data were analyzed and summarized by the method of retrospective case analysis. Results A total of 210 XDRAB strains were detected. The distribution of clinical departments was mainly concentrated in the ICU， with 108 cases （51.4%）. Respiratory diseases （OR = 2.294， 95% CI： 1.018-5.170， P < 0.05）， carbapenems （OR = 12.723， 95% CI： 4.585-35.306， P < 0.05）， quinolones （OR= 10.100， 95% CI： 1.950-52.317， P < 0.05）， β-lactam inhibitors （OR = 4.012， 95% CI： 1.659-9.702， P < 0.05） were the independent risk factors for XDRAB infection. The non-improvement rate in the XDRAB group was higher than that in the non-XDRAB group （χ2 = 94.500， P < 0.05）. Conclusions The proportion of XDRAB isolated from the ICU is the highest. Respiratory diseases and antibacterial drugs （carbapenems， β-lactam inhibitors， quinolones） are the independent risk factors for XDRAB infection. The prognosis of XDRAB infected patients is poor. |
| first_indexed | 2024-04-10T06:05:53Z |
| format | Article |
| id | doaj.art-21b0f79f90224c19b6feb45e2851979a |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-10T06:05:53Z |
| publishDate | 2023-02-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-21b0f79f90224c19b6feb45e2851979a2023-03-03T03:25:48ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022023-02-0154214014310.3969/j.issn.0253-9802.2023.02.011Analysis of risk factors for pulmonary infection caused by extensively drug-resistant Acinetobacter baumanniiBai Xuejiao, Hu Xuejiao, Zhao Yue, Yang Lihui, Ling Yong0△Department of Nosocomial Infection Management， Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University， Guangzhou 510080， ChinaObjective To analyze clinical characteristics and risk factors of pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii （XDRAB）， evaluate antimicrobial therapy and prognosis of XDRAB patients， aiming to provide references for effective prevention and control of nosocomial infection and clinical diagnosis and treatment. Methods Patients with XDRAB isolated from the lower respiratory tract specimens were collected. The number of repeated cases and colonization strains were excluded. The case data were analyzed and summarized by the method of retrospective case analysis. Results A total of 210 XDRAB strains were detected. The distribution of clinical departments was mainly concentrated in the ICU， with 108 cases （51.4%）. Respiratory diseases （OR = 2.294， 95% CI： 1.018-5.170， P < 0.05）， carbapenems （OR = 12.723， 95% CI： 4.585-35.306， P < 0.05）， quinolones （OR= 10.100， 95% CI： 1.950-52.317， P < 0.05）， β-lactam inhibitors （OR = 4.012， 95% CI： 1.659-9.702， P < 0.05） were the independent risk factors for XDRAB infection. The non-improvement rate in the XDRAB group was higher than that in the non-XDRAB group （χ2 = 94.500， P < 0.05）. Conclusions The proportion of XDRAB isolated from the ICU is the highest. Respiratory diseases and antibacterial drugs （carbapenems， β-lactam inhibitors， quinolones） are the independent risk factors for XDRAB infection. The prognosis of XDRAB infected patients is poor.https://www.xinyixue.cn/fileup/0253-9802/PDF/1677813357707-58493010.pdf|extensively drug-resistant acinetobacter baumannii|pulmonary infection|risk factor|clinical medication|prognosis |
| spellingShingle | Bai Xuejiao, Hu Xuejiao, Zhao Yue, Yang Lihui, Ling Yong Analysis of risk factors for pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii Xin yixue |extensively drug-resistant acinetobacter baumannii|pulmonary infection|risk factor|clinical medication|prognosis |
| title | Analysis of risk factors for pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii |
| title_full | Analysis of risk factors for pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii |
| title_fullStr | Analysis of risk factors for pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii |
| title_full_unstemmed | Analysis of risk factors for pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii |
| title_short | Analysis of risk factors for pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii |
| title_sort | analysis of risk factors for pulmonary infection caused by extensively drug resistant acinetobacter baumannii |
| topic | |extensively drug-resistant acinetobacter baumannii|pulmonary infection|risk factor|clinical medication|prognosis |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1677813357707-58493010.pdf |
| work_keys_str_mv | AT baixuejiaohuxuejiaozhaoyueyanglihuilingyong analysisofriskfactorsforpulmonaryinfectioncausedbyextensivelydrugresistantacinetobacterbaumannii |