A Novel Cu(II)-Binding Peptide Identified by Phage Display Inhibits Cu<sup>2+</sup>-Mediated Aβ Aggregation

A Novel Cu(II)-Binding Peptide Identified by Phage Display Inhibits Cu<sup>2+</sup>-Mediated Aβ Aggregation

Copper (Cu) has been implicated in the progression of Alzheimer’s disease (AD), and aggregation of Cu and amyloid β peptide (Aβ) are considered key pathological features of AD. Metal chelators are considered to be potential therapeutic agents for AD because of their capacity to reduce metal ion-indu...

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Bibliographic Details
Main Authors: Xiaoyu Zhang, Xiancheng Zhang, Manli Zhong, Pu Zhao, Chuang Guo, You Li, He Xu, Tao Wang, Huiling Gao
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
phage display
metal-binding peptide
Cu(II)
Aβ
Alzheimer’s disease
Online Access:https://www.mdpi.com/1422-0067/22/13/6842

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https://www.mdpi.com/1422-0067/22/13/6842

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