Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk
It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder ca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-02-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1805994 |
| _version_ | 1827809511208910848 |
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| author | Ugo Fedeli Angelo Porreca Michele Colicchia Elena Schievano Walter Artibani Luigi Roberto Biasio Giorgio Palù |
| author_facet | Ugo Fedeli Angelo Porreca Michele Colicchia Elena Schievano Walter Artibani Luigi Roberto Biasio Giorgio Palù |
| author_sort | Ugo Fedeli |
| collection | DOAJ |
| description | It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated with intra-bladder instillation of BCG, showed no evidence of a protective effect. However, the interpretation of these data need some caution, due to the low prevalence of infection (<1%) observed within this population, along with the fact that intra-bladder administration cannot mirror the usual intradermal administration of BCG, in particular in patients partially immunocompromised. Confirmation by larger prospective studies is required. |
| first_indexed | 2024-03-11T22:42:28Z |
| format | Article |
| id | doaj.art-21b410165849438b888ecc734a67fae5 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:42:28Z |
| publishDate | 2021-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-21b410165849438b888ecc734a67fae52023-09-22T08:51:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-02-0117241641710.1080/21645515.2020.18059941805994Intravescical instillation of Calmette-Guérin bacillus and COVID-19 riskUgo Fedeli0Angelo Porreca1Michele Colicchia2Elena Schievano3Walter Artibani4Luigi Roberto Biasio5Giorgio Palù6Azienda Zero Veneto RegionPoliclinico Abano TermePoliclinico Abano TermeAzienda Zero Veneto RegionPoliclinico Abano TermeUniversity Contract Lecturer inVaccinologyAzienda Zero Veneto RegionIt has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated with intra-bladder instillation of BCG, showed no evidence of a protective effect. However, the interpretation of these data need some caution, due to the low prevalence of infection (<1%) observed within this population, along with the fact that intra-bladder administration cannot mirror the usual intradermal administration of BCG, in particular in patients partially immunocompromised. Confirmation by larger prospective studies is required.http://dx.doi.org/10.1080/21645515.2020.1805994bcgbladder cancercovid-19epidemiology |
| spellingShingle | Ugo Fedeli Angelo Porreca Michele Colicchia Elena Schievano Walter Artibani Luigi Roberto Biasio Giorgio Palù Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk Human Vaccines & Immunotherapeutics bcg bladder cancer covid-19 epidemiology |
| title | Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk |
| title_full | Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk |
| title_fullStr | Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk |
| title_full_unstemmed | Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk |
| title_short | Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk |
| title_sort | intravescical instillation of calmette guerin bacillus and covid 19 risk |
| topic | bcg bladder cancer covid-19 epidemiology |
| url | http://dx.doi.org/10.1080/21645515.2020.1805994 |
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