Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patients
Thymoma screening is recommended at the onset of myasthenia gravis (MG) or when patients with MG present with clinical deterioration or a progressive increase of anti-acetylcholine receptor antibody. However, it is unknown if it is necessary to repeat the screening of thymoma at fixed intervals, eve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2013-07-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700462&lng=en&tlng=en |
| _version_ | 1817991901922459648 |
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| author | Paulo Jose Lorenzoni Lucas Pires Augusto Claudia Suemi Kamoi Kay Rosana Herminia Scola Lineu Cesar Werneck |
| author_facet | Paulo Jose Lorenzoni Lucas Pires Augusto Claudia Suemi Kamoi Kay Rosana Herminia Scola Lineu Cesar Werneck |
| author_sort | Paulo Jose Lorenzoni |
| collection | DOAJ |
| description | Thymoma screening is recommended at the onset of myasthenia gravis (MG) or when patients with MG present with clinical deterioration or a progressive increase of anti-acetylcholine receptor antibody. However, it is unknown if it is necessary to repeat the screening of thymoma at fixed intervals, even in the absence of MG deterioration, when the initial screening is negative. We analyzed the recurrence rate and incidence of new thymoma in a series of patients with well-controlled MG. The sample consisted of 53 patients, aged 17 to 72 years, and the follow-up varied between 75 and 472 months. The chest computerized tomography detected thymus abnormalities in eight patients at the initial screening and no abnormalities in all patients at a second screening after five years. The findings of this study support the classical opinion that screening for thymoma should be recommended only if there is clinical deterioration due to the disease. |
| first_indexed | 2024-04-14T01:19:26Z |
| format | Article |
| id | doaj.art-21b4e363ac7745ef9f596cfa5f55b428 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-04-14T01:19:26Z |
| publishDate | 2013-07-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-21b4e363ac7745ef9f596cfa5f55b4282022-12-22T02:20:41ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272013-07-0171746246410.1590/0004-282X20130062S0004-282X2013000700462Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patientsPaulo Jose LorenzoniLucas Pires AugustoClaudia Suemi Kamoi KayRosana Herminia ScolaLineu Cesar WerneckThymoma screening is recommended at the onset of myasthenia gravis (MG) or when patients with MG present with clinical deterioration or a progressive increase of anti-acetylcholine receptor antibody. However, it is unknown if it is necessary to repeat the screening of thymoma at fixed intervals, even in the absence of MG deterioration, when the initial screening is negative. We analyzed the recurrence rate and incidence of new thymoma in a series of patients with well-controlled MG. The sample consisted of 53 patients, aged 17 to 72 years, and the follow-up varied between 75 and 472 months. The chest computerized tomography detected thymus abnormalities in eight patients at the initial screening and no abnormalities in all patients at a second screening after five years. The findings of this study support the classical opinion that screening for thymoma should be recommended only if there is clinical deterioration due to the disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700462&lng=en&tlng=enmiastenia gravistimotimomatomografia |
| spellingShingle | Paulo Jose Lorenzoni Lucas Pires Augusto Claudia Suemi Kamoi Kay Rosana Herminia Scola Lineu Cesar Werneck Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patients Arquivos de Neuro-Psiquiatria miastenia gravis timo timoma tomografia |
| title | Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patients |
| title_full | Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patients |
| title_fullStr | Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patients |
| title_full_unstemmed | Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patients |
| title_short | Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patients |
| title_sort | myasthenia gravis and thymus long term follow up screening of thymectomized and non thymectomized patients |
| topic | miastenia gravis timo timoma tomografia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700462&lng=en&tlng=en |
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