Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo

Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo

Background: MiR-134 is enriched in dendrites of hippocampal neurons and plays crucial roles in the progress of epilepsy. The present study aims to investigate the effects of antagomirs targeting miroRNA-134 (Ant-134) on limk1 expression and the binding of miR-134 and limk1 in experimental seizure. M...

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Bibliographic Details
Main Authors: Jiahang Sun, Xiaoying Gao, Dawei Meng, Yang Xu, Xichun Wang, Xin Gu, Mian Guo, Xiaodong Shao, Hongwen Yan, Chuanlu Jiang, Yongri Zheng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Epilepsy
MiR-134
Limk1
Cofilin
Hippocampus
Online Access:http://www.karger.com/Article/FullText/480647

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