Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing
Background The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2014-11-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2014.41.6.638 |
| _version_ | 1798005390853537792 |
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| author | Elijah Zhengyang Cai Erin Yiling Teo Lim Jing Yun Pei Koh Tan Si Qian Feng Wen James Wai Kit Lee Eileen Chor Hoong Hing Yan Lin Yap Hanjing Lee Chuen Neng Lee Swee-Hin Teoh Jane Lim Thiam Chye Lim |
| author_facet | Elijah Zhengyang Cai Erin Yiling Teo Lim Jing Yun Pei Koh Tan Si Qian Feng Wen James Wai Kit Lee Eileen Chor Hoong Hing Yan Lin Yap Hanjing Lee Chuen Neng Lee Swee-Hin Teoh Jane Lim Thiam Chye Lim |
| author_sort | Elijah Zhengyang Cai |
| collection | DOAJ |
| description | Background The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.
Methods 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.
Results Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm2, 4.90 cm2, 3.12 cm2, 1.84 cm2; Mepitel (n=6): 10.29 cm2, 5.53 cm2, 3.63 cm2, 2.02 cm2; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.
Conclusions BPM is comparable to Mepitel as a safe and efficacious wound dressing. |
| first_indexed | 2024-04-11T12:38:32Z |
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| id | doaj.art-21b814e3d4d5452bbd3d932e76741d30 |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-11T12:38:32Z |
| publishDate | 2014-11-01 |
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| series | Archives of Plastic Surgery |
| spelling | doaj.art-21b814e3d4d5452bbd3d932e76741d302022-12-22T04:23:33ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712014-11-01410663864610.5999/aps.2014.41.6.638423Bio-Conjugated Polycaprolactone Membranes: A Novel Wound DressingElijah Zhengyang Cai0Erin Yiling Teo1Lim Jing2Yun Pei Koh3Tan Si Qian4Feng Wen5James Wai Kit Lee6Eileen Chor Hoong Hing7Yan Lin Yap8Hanjing Lee9Chuen Neng Lee10Swee-Hin Teoh11Jane Lim12Thiam Chye Lim13Department of Surgery, National University Health System, SingaporeDepartment of Reproductive Medicine, KK Women's and Children Hospital, SingaporeDivision of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, SingaporeDepartment of Surgery, National University Health System, SingaporeCentre for Biomedical Materials Applications and Technology (BIOMAT), Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, SingaporeDivision of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, SingaporeDepartment of Surgery, National University Health System, SingaporeDepartment of Surgery, National University of Singapore, SingaporeDivision of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Health System, SingaporeDivision of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Health System, SingaporeDepartment of Surgery, National University of Singapore, SingaporeDivision of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, SingaporeDepartment of Surgery, National University of Singapore, SingaporeDepartment of Surgery, National University of Singapore, SingaporeBackground The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing. Methods 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration. Results Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm2, 4.90 cm2, 3.12 cm2, 1.84 cm2; Mepitel (n=6): 10.29 cm2, 5.53 cm2, 3.63 cm2, 2.02 cm2; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups. Conclusions BPM is comparable to Mepitel as a safe and efficacious wound dressing.http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2014.41.6.638skinwoundshyaluronic acidpolycaprolactonerabbit |
| spellingShingle | Elijah Zhengyang Cai Erin Yiling Teo Lim Jing Yun Pei Koh Tan Si Qian Feng Wen James Wai Kit Lee Eileen Chor Hoong Hing Yan Lin Yap Hanjing Lee Chuen Neng Lee Swee-Hin Teoh Jane Lim Thiam Chye Lim Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing Archives of Plastic Surgery skin wounds hyaluronic acid polycaprolactone rabbit |
| title | Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing |
| title_full | Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing |
| title_fullStr | Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing |
| title_full_unstemmed | Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing |
| title_short | Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing |
| title_sort | bio conjugated polycaprolactone membranes a novel wound dressing |
| topic | skin wounds hyaluronic acid polycaprolactone rabbit |
| url | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2014.41.6.638 |
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