Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma
Background: Positive-margin resection of external auditory canal squamous cell carcinoma (EAC-SCC) is still a major cause of recurrence. The aim of this study is to examine the clinical impact of positive-margin resection of EAC-SCCs. Methods: We retrospectively reviewed 40 surgical cases with en bl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/17/4289 |
| _version_ | 1797582718108696576 |
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| author | Noritaka Komune Ryosuke Kuga Takahiro Hongo Daisuke Kuga Kuniaki Sato Takashi Nakagawa |
| author_facet | Noritaka Komune Ryosuke Kuga Takahiro Hongo Daisuke Kuga Kuniaki Sato Takashi Nakagawa |
| author_sort | Noritaka Komune |
| collection | DOAJ |
| description | Background: Positive-margin resection of external auditory canal squamous cell carcinoma (EAC-SCC) is still a major cause of recurrence. The aim of this study is to examine the clinical impact of positive-margin resection of EAC-SCCs. Methods: We retrospectively reviewed 40 surgical cases with en bloc temporal bone resection of EAC-SCC at a tertiary referral center from October 2016 to March 2022. Results: Two-year disease-specific, overall, and disease-free survival rates for all 40 cases reviewed were 85.2%, 88.85%, and 76.96%, respectively. En bloc resection with a negative margin significantly improved patient prognosis (<i>p</i> < 0.001). Positive-margin resection was observed in 9/40 cases (22.5%). Insufficient assessment of preoperative images was the cause in two of these cases. Postoperative lymph node metastasis and distant metastasis were observed in cases in which vascular, lymphatic duct or perineural invasion was found on postoperative pathological examination. In addition, three cases in which no vascular, lymphatic duct, or perineural invasion was found exhibited local recurrence during the follow-up period. Of the nine positive-margin resection cases, only two showed no postoperative recurrence. Conclusions: Once positive-margin resections are confirmed, cases might have a high risk of tumor recurrence, even with the addition of postoperative adjuvant chemoradiotherapy. |
| first_indexed | 2024-03-10T23:26:29Z |
| format | Article |
| id | doaj.art-21b97701f2774a60a2ef65b4e7d2a149 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T23:26:29Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-21b97701f2774a60a2ef65b4e7d2a1492023-11-19T07:55:44ZengMDPI AGCancers2072-66942023-08-011517428910.3390/cancers15174289Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell CarcinomaNoritaka Komune0Ryosuke Kuga1Takahiro Hongo2Daisuke Kuga3Kuniaki Sato4Takashi Nakagawa5Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDepartment of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDepartment of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDepartment of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDepartment of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanBackground: Positive-margin resection of external auditory canal squamous cell carcinoma (EAC-SCC) is still a major cause of recurrence. The aim of this study is to examine the clinical impact of positive-margin resection of EAC-SCCs. Methods: We retrospectively reviewed 40 surgical cases with en bloc temporal bone resection of EAC-SCC at a tertiary referral center from October 2016 to March 2022. Results: Two-year disease-specific, overall, and disease-free survival rates for all 40 cases reviewed were 85.2%, 88.85%, and 76.96%, respectively. En bloc resection with a negative margin significantly improved patient prognosis (<i>p</i> < 0.001). Positive-margin resection was observed in 9/40 cases (22.5%). Insufficient assessment of preoperative images was the cause in two of these cases. Postoperative lymph node metastasis and distant metastasis were observed in cases in which vascular, lymphatic duct or perineural invasion was found on postoperative pathological examination. In addition, three cases in which no vascular, lymphatic duct, or perineural invasion was found exhibited local recurrence during the follow-up period. Of the nine positive-margin resection cases, only two showed no postoperative recurrence. Conclusions: Once positive-margin resections are confirmed, cases might have a high risk of tumor recurrence, even with the addition of postoperative adjuvant chemoradiotherapy.https://www.mdpi.com/2072-6694/15/17/4289external auditory canalsquamous cell carcinomatemporal bonesurgical marginskull base surgery |
| spellingShingle | Noritaka Komune Ryosuke Kuga Takahiro Hongo Daisuke Kuga Kuniaki Sato Takashi Nakagawa Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma Cancers external auditory canal squamous cell carcinoma temporal bone surgical margin skull base surgery |
| title | Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma |
| title_full | Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma |
| title_fullStr | Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma |
| title_full_unstemmed | Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma |
| title_short | Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma |
| title_sort | impact of positive margin resection of external auditory canal squamous cell carcinoma |
| topic | external auditory canal squamous cell carcinoma temporal bone surgical margin skull base surgery |
| url | https://www.mdpi.com/2072-6694/15/17/4289 |
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