Prognostic Implications of Postoperative Infectious Complications in Non-Small Cell Lung Cancer
Background: Few studies have evaluated the long-term impact of postoperative infectious complications in patients with non-small cell lung cancer (NSCLC). We aimed to determine the impact of infectious complications on long-term outcomes after surgical resection for NSCLC. Methods: We performed a...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Korean Society for Thoracic and Cardiovascular Surgery
2018-02-01
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Series: | Korean Journal of Thoracic and Cardiovascular Surgery |
Subjects: | |
Online Access: | http://www.kjtcvs.org/journal/download_pdf.php?doi=10.5090/kjtcs.2018.51.1.41 |
Summary: | Background: Few studies have evaluated the long-term impact of postoperative infectious complications in patients
with non-small cell lung cancer (NSCLC). We aimed to determine the impact of infectious complications
on long-term outcomes after surgical resection for NSCLC. Methods: We performed a retrospective study of
1,380 eligible patients who underwent pulmonary resection for NSCLC from 2003 to 2012. Complications
were divided into infectious complications and non-infectious complications. Kaplan-Meier survival analysis
was used to compare unadjusted 5-year cancer-specific survival (CSS) rates and recurrence-free survival
(RFS) rates. Cox regression was used to determine the impact of infectious complications on 5-year CSS and
RFS. Results: The rate of total complications and infectious complications was 24.3% and 4.3%, respectively.
In the node-negative subgroup, the 5-year CSS and RFS rates were 75.9% and 57.1% in patients who had
infectious complications, compared to 87.9% and 78.4% in patients who had no complications. Infectious
complications were a negative prognostic factor for 5-year RFS (hazard ratio, 1.92; 95% confidence interval,
1.00–3.69; p=0.049). In the node-positive subgroup, the 5-year CSS rate and RFS were 44.6% and 48.4% in
patients who had infectious complications, compared to 70.5% and 48.4% for patients who had no
complications. Conclusion: Postoperative infectious complications had a negative impact on CSS and RFS in
node-negative NSCLC. Our findings may help improve risk assessment for tumor recurrence after pulmonary
resection for node-negative NSCLC. |
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ISSN: | 2233-601X 2093-6516 |