Hybrid odontogenic lesions: A case series of a rare entity
Background: The occurrence of hybrid odontogenic lesions with two or more morphologically distinct components is a rare phenomenon and poses a diagnostic challenge. We aimed to study the clinical, radiological, and pathological features and behavior of hybrid odontogenic lesions, to enhance awarenes...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402303428X |
| _version_ | 1827937364518895616 |
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| author | Muhammad Raza Arsalan Ahmed Jamshid Abdul-Ghafar Rashida Ahmed Nasir Ud Din |
| author_facet | Muhammad Raza Arsalan Ahmed Jamshid Abdul-Ghafar Rashida Ahmed Nasir Ud Din |
| author_sort | Muhammad Raza |
| collection | DOAJ |
| description | Background: The occurrence of hybrid odontogenic lesions with two or more morphologically distinct components is a rare phenomenon and poses a diagnostic challenge. We aimed to study the clinical, radiological, and pathological features and behavior of hybrid odontogenic lesions, to enhance awareness about these rare lesions. Method: Hematoxylin and Eosin slides of hybrid odontogenic lesions diagnosed between January 01, 2012 and December 31, 2020, were reviewed. Demographic and radiological information were obtained from the patient's medical records. Results: 8 cases were diagnosed with a mean age of 19.1 years and male to female ratio of 1:1.7. Involvement of mandible was more common (n = 5) as compared to maxilla (n = 3). All patients presented with swelling for an average of 9.75 months (3–25 months) duration. Bleeding, loose teeth, pain and facial asymmetry were reported in 5,3, 3, and 2 cases, respectively. Radiologically, 7 cases were well demarcated, 75% cases (n = 6) were radiolucent, and average radiological size was 4.8 cm. All patients were managed with surgery alone. 5 cases (62.5%) underwent enucleation and curettage, while local excision, en-block resection and segmental mandibulectomy were performed in 1 case each. Histologically, ossifying fibroma/cemento-ossifyiong fibroma were the most lesion, occurring in 5 cases (62%), followed by giant cell granuloma like lesions (GCG) i.e., central and peripheral giant cell granuloma (n = 3), Adenomatoid Odontogenic tumor (AOT) (n = 2), and DC (n = 2), ameloblastic fibroma (AF) (n = 1), Ameloblastoma (n = 1), calcifying odontogenic cyst (COC) (n = 1), and complex odontoma (n = 1). No evidence of recurrence was noted after 4–99 months of surgery (mean: 32.9) in cases with available data (n = 7). Long-term complaints included facial asymmetry (n = 2) and pain (n = 1). Conclusion: Most hybrid odontogenic lesions affect young females in the second decade of life and commonly show COF and OF as hybrid components. A conservative approach to management appears adequate. |
| first_indexed | 2024-03-13T08:24:33Z |
| format | Article |
| id | doaj.art-21baff72bac14204aa9f8a7254fb08d1 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:24:33Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-21baff72bac14204aa9f8a7254fb08d12023-05-31T04:46:58ZengElsevierHeliyon2405-84402023-05-0195e16221Hybrid odontogenic lesions: A case series of a rare entityMuhammad Raza0Arsalan Ahmed1Jamshid Abdul-Ghafar2Rashida Ahmed3Nasir Ud Din4Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, PakistanDepartment of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, PakistanDepartment of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan; Corresponding author.Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, PakistanDepartment of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, PakistanBackground: The occurrence of hybrid odontogenic lesions with two or more morphologically distinct components is a rare phenomenon and poses a diagnostic challenge. We aimed to study the clinical, radiological, and pathological features and behavior of hybrid odontogenic lesions, to enhance awareness about these rare lesions. Method: Hematoxylin and Eosin slides of hybrid odontogenic lesions diagnosed between January 01, 2012 and December 31, 2020, were reviewed. Demographic and radiological information were obtained from the patient's medical records. Results: 8 cases were diagnosed with a mean age of 19.1 years and male to female ratio of 1:1.7. Involvement of mandible was more common (n = 5) as compared to maxilla (n = 3). All patients presented with swelling for an average of 9.75 months (3–25 months) duration. Bleeding, loose teeth, pain and facial asymmetry were reported in 5,3, 3, and 2 cases, respectively. Radiologically, 7 cases were well demarcated, 75% cases (n = 6) were radiolucent, and average radiological size was 4.8 cm. All patients were managed with surgery alone. 5 cases (62.5%) underwent enucleation and curettage, while local excision, en-block resection and segmental mandibulectomy were performed in 1 case each. Histologically, ossifying fibroma/cemento-ossifyiong fibroma were the most lesion, occurring in 5 cases (62%), followed by giant cell granuloma like lesions (GCG) i.e., central and peripheral giant cell granuloma (n = 3), Adenomatoid Odontogenic tumor (AOT) (n = 2), and DC (n = 2), ameloblastic fibroma (AF) (n = 1), Ameloblastoma (n = 1), calcifying odontogenic cyst (COC) (n = 1), and complex odontoma (n = 1). No evidence of recurrence was noted after 4–99 months of surgery (mean: 32.9) in cases with available data (n = 7). Long-term complaints included facial asymmetry (n = 2) and pain (n = 1). Conclusion: Most hybrid odontogenic lesions affect young females in the second decade of life and commonly show COF and OF as hybrid components. A conservative approach to management appears adequate.http://www.sciencedirect.com/science/article/pii/S240584402303428XHybridCemento-ossifying fibromaOssifying fibromaAdenomatoid odontogenic tumorAmeloblastic fibromaCalcifying odontogenic cyst |
| spellingShingle | Muhammad Raza Arsalan Ahmed Jamshid Abdul-Ghafar Rashida Ahmed Nasir Ud Din Hybrid odontogenic lesions: A case series of a rare entity Heliyon Hybrid Cemento-ossifying fibroma Ossifying fibroma Adenomatoid odontogenic tumor Ameloblastic fibroma Calcifying odontogenic cyst |
| title | Hybrid odontogenic lesions: A case series of a rare entity |
| title_full | Hybrid odontogenic lesions: A case series of a rare entity |
| title_fullStr | Hybrid odontogenic lesions: A case series of a rare entity |
| title_full_unstemmed | Hybrid odontogenic lesions: A case series of a rare entity |
| title_short | Hybrid odontogenic lesions: A case series of a rare entity |
| title_sort | hybrid odontogenic lesions a case series of a rare entity |
| topic | Hybrid Cemento-ossifying fibroma Ossifying fibroma Adenomatoid odontogenic tumor Ameloblastic fibroma Calcifying odontogenic cyst |
| url | http://www.sciencedirect.com/science/article/pii/S240584402303428X |
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