Effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in Babylon, Iraq
Background: Infertility is the inability to get pregnant after engaging in unprotected sexual activity for at least a year. Obesity and overweight are terms used to describe abnormal or excessive weight growth that is harmful to one’s health. Objectives: The aim of this study was to measure the andr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Medical Journal of Babylon |
| Subjects: | |
| Online Access: | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=2;spage=433;epage=436;aulast=Mari |
| _version_ | 1797645414011240448 |
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| author | Zainab Mohammed Mari Maha F Smaism Nadia Mudher Al-Hilli |
| author_facet | Zainab Mohammed Mari Maha F Smaism Nadia Mudher Al-Hilli |
| author_sort | Zainab Mohammed Mari |
| collection | DOAJ |
| description | Background: Infertility is the inability to get pregnant after engaging in unprotected sexual activity for at least a year. Obesity and overweight are terms used to describe abnormal or excessive weight growth that is harmful to one’s health. Objectives: The aim of this study was to measure the androgen receptor (AR), total and free testosterone, and dehydroepiandrosterone sulfates (DHEA-S) levels in the serum of Iraqi women who were having trouble getting pregnant and study the change of these parameters in the case of obesity and infertility. Materials and Methods: The case–control group was made up of 45 additional, presumably healthy women, whereas the sick group was made up of 45 obese infertile women. A study was carried out in the Babylon teaching hospital for maternity and children in Hilla city and private clinics from July to January 2022. An enzyme-linked immunosorbent assay (ELISA) was used to evaluate the serum concentrations of DHEA-S, total testosterone, and free testosterone (ELISA). SPSS software was used to conduct the statistical analysis. Results: A considerable drop in total testosterone and AR levels, infertile women exhibited significantly greater serum levels of free testosterone and DHEA-S than the control group (P > 0.05). Conclusion: Infertile women had considerably lower serum levels of total testosterone and ARs and significantly higher serum levels of free testosterone and DHEA-S. On the basis of the results of this investigation, obesity participates in the pathogenesis of infertility. |
| first_indexed | 2024-03-11T14:46:56Z |
| format | Article |
| id | doaj.art-21bb6fa972c44447894ff351e51e6486 |
| institution | Directory Open Access Journal |
| issn | 1812-156X 2312-6760 |
| language | English |
| last_indexed | 2024-03-11T14:46:56Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj.art-21bb6fa972c44447894ff351e51e64862023-10-30T10:46:24ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602023-01-0120243343610.4103/MJBL.MJBL_187_23Effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in Babylon, IraqZainab Mohammed MariMaha F SmaismNadia Mudher Al-HilliBackground: Infertility is the inability to get pregnant after engaging in unprotected sexual activity for at least a year. Obesity and overweight are terms used to describe abnormal or excessive weight growth that is harmful to one’s health. Objectives: The aim of this study was to measure the androgen receptor (AR), total and free testosterone, and dehydroepiandrosterone sulfates (DHEA-S) levels in the serum of Iraqi women who were having trouble getting pregnant and study the change of these parameters in the case of obesity and infertility. Materials and Methods: The case–control group was made up of 45 additional, presumably healthy women, whereas the sick group was made up of 45 obese infertile women. A study was carried out in the Babylon teaching hospital for maternity and children in Hilla city and private clinics from July to January 2022. An enzyme-linked immunosorbent assay (ELISA) was used to evaluate the serum concentrations of DHEA-S, total testosterone, and free testosterone (ELISA). SPSS software was used to conduct the statistical analysis. Results: A considerable drop in total testosterone and AR levels, infertile women exhibited significantly greater serum levels of free testosterone and DHEA-S than the control group (P > 0.05). Conclusion: Infertile women had considerably lower serum levels of total testosterone and ARs and significantly higher serum levels of free testosterone and DHEA-S. On the basis of the results of this investigation, obesity participates in the pathogenesis of infertility.http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=2;spage=433;epage=436;aulast=Mariandrogendhea-sobesityshbgtestosterone |
| spellingShingle | Zainab Mohammed Mari Maha F Smaism Nadia Mudher Al-Hilli Effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in Babylon, Iraq Medical Journal of Babylon androgen dhea-s obesity shbg testosterone |
| title | Effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in Babylon, Iraq |
| title_full | Effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in Babylon, Iraq |
| title_fullStr | Effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in Babylon, Iraq |
| title_full_unstemmed | Effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in Babylon, Iraq |
| title_short | Effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in Babylon, Iraq |
| title_sort | effect of obesity on androgen receptor and androgen levels in the serum of women with infertility in babylon iraq |
| topic | androgen dhea-s obesity shbg testosterone |
| url | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=2;spage=433;epage=436;aulast=Mari |
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