Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management
Acinetobacter baumannii, a non-motile, glucose non fermentative, oxidase negative, encapsulated, gram-negative coccobacillus, has recently gained importance because of its increasing resistance to the available antibiotics. Three main mechanisms of resistance in A. baumannii are: enzymes inactivat...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2013-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3626/58-%206337_E(C)_F(T)_PF1(Pr_PP)_PFA(NC).pdf |
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| author | Harmanjit Singh Pugazhenthan Thangaraj Amitava Chakrabarti |
| author_facet | Harmanjit Singh Pugazhenthan Thangaraj Amitava Chakrabarti |
| author_sort | Harmanjit Singh |
| collection | DOAJ |
| description | Acinetobacter baumannii, a non-motile, glucose non fermentative, oxidase negative, encapsulated, gram-negative coccobacillus, has
recently gained importance because of its increasing resistance to the available antibiotics. Three main mechanisms of resistance in A.
baumannii are: enzymes inactivating antibiotics, reduced entry into the target site of bacteria and alteration of the target or cellular functions
due to mutations. Multi-drug resistant A. Baumannii, including carbapenam resistant A. Baumannii, are posing a potential threat to mankind
by causing lethal infections, especially in ICU set up and in patients who are on ventilators, for which our conventional antibiotics were not
shown to be effective. Many reports have indicated carbapenam resistance among A. Baumannii and only colistin and tigecyclyne have
shown some promise in combating this lethal microorganism. |
| first_indexed | 2024-12-21T11:06:52Z |
| format | Article |
| id | doaj.art-21bcdecb39a74b75b9fcc03e6f7e232d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T11:06:52Z |
| publishDate | 2013-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-21bcdecb39a74b75b9fcc03e6f7e232d2022-12-21T19:06:12ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-11-017112602260510.7860/JCDR/2013/6337.3626Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic ManagementHarmanjit Singh0Pugazhenthan Thangaraj1Amitava Chakrabarti2Senior Resident, Department of Pharmacology, PGIMER, Chandigarh, India. Junior Resident, Department of Pharmacology, PGIMER, Chandigarh, India.Professor and Head, Department of Pharmacology, PGIMER, Chandigarh, India.Acinetobacter baumannii, a non-motile, glucose non fermentative, oxidase negative, encapsulated, gram-negative coccobacillus, has recently gained importance because of its increasing resistance to the available antibiotics. Three main mechanisms of resistance in A. baumannii are: enzymes inactivating antibiotics, reduced entry into the target site of bacteria and alteration of the target or cellular functions due to mutations. Multi-drug resistant A. Baumannii, including carbapenam resistant A. Baumannii, are posing a potential threat to mankind by causing lethal infections, especially in ICU set up and in patients who are on ventilators, for which our conventional antibiotics were not shown to be effective. Many reports have indicated carbapenam resistance among A. Baumannii and only colistin and tigecyclyne have shown some promise in combating this lethal microorganism.https://jcdr.net/articles/PDF/3626/58-%206337_E(C)_F(T)_PF1(Pr_PP)_PFA(NC).pdfa. baumanniimdr-abcrabcolistin |
| spellingShingle | Harmanjit Singh Pugazhenthan Thangaraj Amitava Chakrabarti Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management Journal of Clinical and Diagnostic Research a. baumannii mdr-ab crab colistin |
| title | Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management |
| title_full | Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management |
| title_fullStr | Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management |
| title_full_unstemmed | Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management |
| title_short | Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management |
| title_sort | acinetobacter baumannii a brief account of mechanisms of multidrug resistance and current and future therapeutic management |
| topic | a. baumannii mdr-ab crab colistin |
| url | https://jcdr.net/articles/PDF/3626/58-%206337_E(C)_F(T)_PF1(Pr_PP)_PFA(NC).pdf |
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