Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis
Tetrabromobisphenol A (TBBPA), Tetrachlorobisphenol A (TCBPA), Tetrabromobisphenol S (TBBPS) and their derivatives as the most widely used halogenated flame retardants (HFR), had been employed in the manufacturing industry to raise fire safety. HFRs have been shown to be developmentally toxic to ani...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323002403 |
| _version_ | 1811155534631403520 |
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| author | Lufang Su Dandan Guo Heping Wan Ping Wang Lan Cao Yanmin Long Chaohui Chen Yangyang Song Yonghong Zhang Changli Zeng Rui Guo Xiaoyun Liu |
| author_facet | Lufang Su Dandan Guo Heping Wan Ping Wang Lan Cao Yanmin Long Chaohui Chen Yangyang Song Yonghong Zhang Changli Zeng Rui Guo Xiaoyun Liu |
| author_sort | Lufang Su |
| collection | DOAJ |
| description | Tetrabromobisphenol A (TBBPA), Tetrachlorobisphenol A (TCBPA), Tetrabromobisphenol S (TBBPS) and their derivatives as the most widely used halogenated flame retardants (HFR), had been employed in the manufacturing industry to raise fire safety. HFRs have been shown to be developmentally toxic to animals and also affect plant growth. However, little was known about the molecular mechanism responded by when plants were treated with these compounds. In this study, when Arabidopsis was exposed to four HFRs (TBBPA, TCBPA, TBBPS-MDHP, TBBPS), the stress of these compounds had different inhibitory effects on seed germination and plant growth. Transcriptome and metabolome analysis showed that all four HFRs could influence the expression of transmembrane transporters to affect ion transport, Phenylpropanoid biosynthesis, Plant-pathogen interaction, MAPK signalling pathway and other pathways. In addition, the effects of different kinds of HFR on plants also have variant characteristics. It is very fascinating that Arabidopsis shows the response of biotic stress after exposure to these kinds of compounds, including the immune mechanism. Overall, the findings of the mechanism recovered by methods of transcriptome and metabolome analysis supplied a vital insight into the molecular perspective for Arabidopsis response to HFRs stress. |
| first_indexed | 2024-04-10T04:34:43Z |
| format | Article |
| id | doaj.art-21bce3da2a2644cb8594849abd1283d6 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-10T04:34:43Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-21bce3da2a2644cb8594849abd1283d62023-03-10T04:34:04ZengElsevierEcotoxicology and Environmental Safety0147-65132023-04-01254114736Transcriptomic and metabolomic insights into the defense response to HFRs in ArabidopsisLufang Su0Dandan Guo1Heping Wan2Ping Wang3Lan Cao4Yanmin Long5Chaohui Chen6Yangyang Song7Yonghong Zhang8Changli Zeng9Rui Guo10Xiaoyun Liu11Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, College of Life Sciences, Jianghan University, Wuhan 430056, ChinaHubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, College of Life Sciences, Jianghan University, Wuhan 430056, ChinaHubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, College of Life Sciences, Jianghan University, Wuhan 430056, ChinaHubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, College of Life Sciences, Jianghan University, Wuhan 430056, ChinaHubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, College of Life Sciences, Jianghan University, Wuhan 430056, ChinaHubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, College of Life Sciences, Jianghan University, Wuhan 430056, ChinaKey Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, College of Photoelectric Materials and Technology, Jianghan University, Wuhan 430056, ChinaHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, ChinaLaboratory of Medicinal Plant, Institute of Basic Medical Sciences, School of Basic Medicine, Biomedical Research Institute, Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan 442000, ChinaHubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, College of Life Sciences, Jianghan University, Wuhan 430056, China; Corresponding authors.Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China; Corresponding authors.Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin, College of Life Sciences, Jianghan University, Wuhan 430056, China; Corresponding authors.Tetrabromobisphenol A (TBBPA), Tetrachlorobisphenol A (TCBPA), Tetrabromobisphenol S (TBBPS) and their derivatives as the most widely used halogenated flame retardants (HFR), had been employed in the manufacturing industry to raise fire safety. HFRs have been shown to be developmentally toxic to animals and also affect plant growth. However, little was known about the molecular mechanism responded by when plants were treated with these compounds. In this study, when Arabidopsis was exposed to four HFRs (TBBPA, TCBPA, TBBPS-MDHP, TBBPS), the stress of these compounds had different inhibitory effects on seed germination and plant growth. Transcriptome and metabolome analysis showed that all four HFRs could influence the expression of transmembrane transporters to affect ion transport, Phenylpropanoid biosynthesis, Plant-pathogen interaction, MAPK signalling pathway and other pathways. In addition, the effects of different kinds of HFR on plants also have variant characteristics. It is very fascinating that Arabidopsis shows the response of biotic stress after exposure to these kinds of compounds, including the immune mechanism. Overall, the findings of the mechanism recovered by methods of transcriptome and metabolome analysis supplied a vital insight into the molecular perspective for Arabidopsis response to HFRs stress.http://www.sciencedirect.com/science/article/pii/S0147651323002403ArabidopsisHalogenated flame retardantsMetabolomePhysiologyTranscriptome |
| spellingShingle | Lufang Su Dandan Guo Heping Wan Ping Wang Lan Cao Yanmin Long Chaohui Chen Yangyang Song Yonghong Zhang Changli Zeng Rui Guo Xiaoyun Liu Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis Ecotoxicology and Environmental Safety Arabidopsis Halogenated flame retardants Metabolome Physiology Transcriptome |
| title | Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis |
| title_full | Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis |
| title_fullStr | Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis |
| title_full_unstemmed | Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis |
| title_short | Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis |
| title_sort | transcriptomic and metabolomic insights into the defense response to hfrs in arabidopsis |
| topic | Arabidopsis Halogenated flame retardants Metabolome Physiology Transcriptome |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323002403 |
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