The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis
<p>Abstract</p> <p>Background</p> <p>Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-11-01
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| Series: | BMC Public Health |
| Online Access: | http://www.biomedcentral.com/1471-2458/10/706 |
| _version_ | 1818352662000697344 |
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| author | Szklo Moyses Tsai Michael Y Jenny Nancy S Diez-Roux Ana V Nazmi Aydin Aiello Allison E |
| author_facet | Szklo Moyses Tsai Michael Y Jenny Nancy S Diez-Roux Ana V Nazmi Aydin Aiello Allison E |
| author_sort | Szklo Moyses |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pathogens have not been examined in relation to inflammation.</p> <p>Methods</p> <p>Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, <it>Helicobacter pylori </it>and <it>Chlamydia pneumoniae</it>. We tested the hypothesis that the number of seropositive pathogens (based on conventional cut-off points) would not be as sensitive a marker of inflammation as immune response measured by antibody levels to pathogens.</p> <p>Results</p> <p>High antibody response to multiple pathogens showed graded and significant associations with IL-6 (p < 0.001), CRP (p = 0.04) and fibrinogen (p = 0.001), whereas seropositive pathogen burden did not. In multiple linear regression models, high antibody response to multiple pathogens maintained a positive association only with IL-6 (4.4% per pathogen exhibiting high antibody response, 95% CI 0.0-8.9).</p> <p>Conclusions</p> <p>High antibody response to pathogens was a more consistent marker of inflammatory outcomes compared to seropositivity alone and high antibody response to multiple pathogens was a stronger marker compared to any single pathogen.</p> |
| first_indexed | 2024-12-13T18:57:11Z |
| format | Article |
| id | doaj.art-21bd1b518d8a4c998c07e911c30aee19 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-13T18:57:11Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-21bd1b518d8a4c998c07e911c30aee192022-12-21T23:34:46ZengBMCBMC Public Health1471-24582010-11-0110170610.1186/1471-2458-10-706The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of AtherosclerosisSzklo MoysesTsai Michael YJenny Nancy SDiez-Roux Ana VNazmi AydinAiello Allison E<p>Abstract</p> <p>Background</p> <p>Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pathogens have not been examined in relation to inflammation.</p> <p>Methods</p> <p>Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, <it>Helicobacter pylori </it>and <it>Chlamydia pneumoniae</it>. We tested the hypothesis that the number of seropositive pathogens (based on conventional cut-off points) would not be as sensitive a marker of inflammation as immune response measured by antibody levels to pathogens.</p> <p>Results</p> <p>High antibody response to multiple pathogens showed graded and significant associations with IL-6 (p < 0.001), CRP (p = 0.04) and fibrinogen (p = 0.001), whereas seropositive pathogen burden did not. In multiple linear regression models, high antibody response to multiple pathogens maintained a positive association only with IL-6 (4.4% per pathogen exhibiting high antibody response, 95% CI 0.0-8.9).</p> <p>Conclusions</p> <p>High antibody response to pathogens was a more consistent marker of inflammatory outcomes compared to seropositivity alone and high antibody response to multiple pathogens was a stronger marker compared to any single pathogen.</p>http://www.biomedcentral.com/1471-2458/10/706 |
| spellingShingle | Szklo Moyses Tsai Michael Y Jenny Nancy S Diez-Roux Ana V Nazmi Aydin Aiello Allison E The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis BMC Public Health |
| title | The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis |
| title_full | The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis |
| title_fullStr | The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis |
| title_full_unstemmed | The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis |
| title_short | The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis |
| title_sort | influence of persistent pathogens on circulating levels of inflammatory markers a cross sectional analysis from the multi ethnic study of atherosclerosis |
| url | http://www.biomedcentral.com/1471-2458/10/706 |
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