Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infections
Inflammatory damage from bacterial biofilms usually causes the failure of tooth implantation. A promising solution for this challenge is to use an implant surface with a long-term, in-depth and efficient antibacterial feature. In this study, we developed an ultrasound-enhanced antibacterial implant...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1074083/full |
| _version_ | 1811224481371258880 |
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| author | Yue Sun Yue Sun Wenzhou Xu Cong Jiang Tianyu Zhou Qiqi Wang Lan A Lan A |
| author_facet | Yue Sun Yue Sun Wenzhou Xu Cong Jiang Tianyu Zhou Qiqi Wang Lan A Lan A |
| author_sort | Yue Sun |
| collection | DOAJ |
| description | Inflammatory damage from bacterial biofilms usually causes the failure of tooth implantation. A promising solution for this challenge is to use an implant surface with a long-term, in-depth and efficient antibacterial feature. In this study, we developed an ultrasound-enhanced antibacterial implant surface based on Au nanoparticle modified TiO2 nanotubes (AuNPs-TNTs). As an artificial tooth surface, films based on AuNPs-TNTs showed excellent biocompatibility. Importantly, compared to bare titania surface, a larger amount of reactive oxygen radicals was generated on AuNPs-TNTs under an ultrasound treatment. For a proof-of-concept application, Porphyromonas gingivalis (P. gingivalis) was used as the model bacteria; the as-proposed AuNPs-TNTs exhibited significantly enhanced antibacterial activity under a simple ultrasound treatment. This antibacterial film offers a new way to design the surface of an artificial implant coating for resolving the bacterial infection induced failure of dental implants. |
| first_indexed | 2024-04-12T08:50:13Z |
| format | Article |
| id | doaj.art-21bd2ebb170048d38f6c15a15bb13f9c |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T08:50:13Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-21bd2ebb170048d38f6c15a15bb13f9c2022-12-22T03:39:36ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-11-011010.3389/fbioe.2022.10740831074083Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infectionsYue Sun0Yue Sun1Wenzhou Xu2Cong Jiang3Tianyu Zhou4Qiqi Wang5Lan A6Lan A7Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Changchun, ChinaDepartment of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, ChinaJilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Changchun, ChinaInflammatory damage from bacterial biofilms usually causes the failure of tooth implantation. A promising solution for this challenge is to use an implant surface with a long-term, in-depth and efficient antibacterial feature. In this study, we developed an ultrasound-enhanced antibacterial implant surface based on Au nanoparticle modified TiO2 nanotubes (AuNPs-TNTs). As an artificial tooth surface, films based on AuNPs-TNTs showed excellent biocompatibility. Importantly, compared to bare titania surface, a larger amount of reactive oxygen radicals was generated on AuNPs-TNTs under an ultrasound treatment. For a proof-of-concept application, Porphyromonas gingivalis (P. gingivalis) was used as the model bacteria; the as-proposed AuNPs-TNTs exhibited significantly enhanced antibacterial activity under a simple ultrasound treatment. This antibacterial film offers a new way to design the surface of an artificial implant coating for resolving the bacterial infection induced failure of dental implants.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1074083/fullsonodynamic therapytitania nanotubeantibacterialdental implantROS |
| spellingShingle | Yue Sun Yue Sun Wenzhou Xu Cong Jiang Tianyu Zhou Qiqi Wang Lan A Lan A Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infections Frontiers in Bioengineering and Biotechnology sonodynamic therapy titania nanotube antibacterial dental implant ROS |
| title | Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infections |
| title_full | Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infections |
| title_fullStr | Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infections |
| title_full_unstemmed | Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infections |
| title_short | Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infections |
| title_sort | gold nanoparticle decoration potentiate the antibacterial enhancement of tio2 nanotubes via sonodynamic therapy against peri implant infections |
| topic | sonodynamic therapy titania nanotube antibacterial dental implant ROS |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1074083/full |
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