The effect of acute and chronic exercise on circulating GDF-15: a systematic review and meta-analysis
Background and Aim: Growth differentiation factor 15 (GDF15) is a cytokine with anti-inflammatory effects, which the influences of acute and chronic exercise on it are not clearly known. Therefore, the aim of the present meta-analysis was to determine the effect of the acute and chronic exercise on...
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| Format: | Article |
| Language: | fas |
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Kashan University of Medical Sciences and Health Services
2023-08-01
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| Series: | Fiyz̤ |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-4934-en.html |
| _version_ | 1797650392146771968 |
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| author | Mousa Khalafi Amir Ghanbarpour Nosrati Razieh sadat Mostafavi Fatemeh Hosseini Jebeli |
| author_facet | Mousa Khalafi Amir Ghanbarpour Nosrati Razieh sadat Mostafavi Fatemeh Hosseini Jebeli |
| author_sort | Mousa Khalafi |
| collection | DOAJ |
| description | Background and Aim: Growth differentiation factor 15 (GDF15) is a cytokine with anti-inflammatory effects, which the influences of acute and chronic exercise on it are not clearly known. Therefore, the aim of the present meta-analysis was to determine the effect of the acute and chronic exercise on circulating GDF15.
Methods: To extract original articles published in Farsi and English language journals, a comprehensive search was conducted in PubMed, Web of Science, Scopus, Magiran, Noormags and SID databases until December 22, 2022. Two separate meta-analyses were performed to calculate the effect size of standardized mean difference (SMD) and 95% confidence interval for the acute and chronic effects of exercise on GDF15.
Results: A total of 18 studies including 551 subjects were included in the meta-analysis. The results showed that acute exercise activity leads to a significant increase in GDF15 [P=0.001, (1.65 to 0.80 CI: 1.23)], while chronic exercise activity had no significant effect on GDF15 [P=0.24, (0.96 to 0.24-CI: 0.35)].
Conclusion: Exercise leads to a transient and short-term increase in GDF15, which may contribute to the beneficial metabolic effects of exercise. |
| first_indexed | 2024-03-11T16:00:42Z |
| format | Article |
| id | doaj.art-21be126c2a404662a44ef2a20a93f7f3 |
| institution | Directory Open Access Journal |
| issn | 1029-7855 2008-9821 |
| language | fas |
| last_indexed | 2024-03-11T16:00:42Z |
| publishDate | 2023-08-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-21be126c2a404662a44ef2a20a93f7f32023-10-25T07:07:25ZfasKashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212023-08-01274461472The effect of acute and chronic exercise on circulating GDF-15: a systematic review and meta-analysisMousa Khalafi0Amir Ghanbarpour Nosrati1Razieh sadat Mostafavi2Fatemeh Hosseini Jebeli3 Department of Physical Education and Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran Department of Physical Education and Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran Department of Physical Education and Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran Department of Physical Education and Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran Background and Aim: Growth differentiation factor 15 (GDF15) is a cytokine with anti-inflammatory effects, which the influences of acute and chronic exercise on it are not clearly known. Therefore, the aim of the present meta-analysis was to determine the effect of the acute and chronic exercise on circulating GDF15. Methods: To extract original articles published in Farsi and English language journals, a comprehensive search was conducted in PubMed, Web of Science, Scopus, Magiran, Noormags and SID databases until December 22, 2022. Two separate meta-analyses were performed to calculate the effect size of standardized mean difference (SMD) and 95% confidence interval for the acute and chronic effects of exercise on GDF15. Results: A total of 18 studies including 551 subjects were included in the meta-analysis. The results showed that acute exercise activity leads to a significant increase in GDF15 [P=0.001, (1.65 to 0.80 CI: 1.23)], while chronic exercise activity had no significant effect on GDF15 [P=0.24, (0.96 to 0.24-CI: 0.35)]. Conclusion: Exercise leads to a transient and short-term increase in GDF15, which may contribute to the beneficial metabolic effects of exercise.http://feyz.kaums.ac.ir/article-1-4934-en.htmlexercisegdf15cytokine |
| spellingShingle | Mousa Khalafi Amir Ghanbarpour Nosrati Razieh sadat Mostafavi Fatemeh Hosseini Jebeli The effect of acute and chronic exercise on circulating GDF-15: a systematic review and meta-analysis Fiyz̤ exercise gdf15 cytokine |
| title | The effect of acute and chronic exercise on circulating GDF-15: a systematic review and meta-analysis |
| title_full | The effect of acute and chronic exercise on circulating GDF-15: a systematic review and meta-analysis |
| title_fullStr | The effect of acute and chronic exercise on circulating GDF-15: a systematic review and meta-analysis |
| title_full_unstemmed | The effect of acute and chronic exercise on circulating GDF-15: a systematic review and meta-analysis |
| title_short | The effect of acute and chronic exercise on circulating GDF-15: a systematic review and meta-analysis |
| title_sort | effect of acute and chronic exercise on circulating gdf 15 a systematic review and meta analysis |
| topic | exercise gdf15 cytokine |
| url | http://feyz.kaums.ac.ir/article-1-4934-en.html |
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