Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature
Oral and maxillofacial tissue defects caused by trauma, tumor reactions, congenital anomalies, ischemic diseases, infectious diseases, surgical resection, and odontogenic cysts present a formidable challenge for reconstruction. Tissue regeneration using functional biomaterials and cell therapy strat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/594 |
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| author | Niloufar Abedi Zahra Sadat Sajadi-Javan Monireh Kouhi Legha Ansari Abbasali Khademi Seeram Ramakrishna |
| author_facet | Niloufar Abedi Zahra Sadat Sajadi-Javan Monireh Kouhi Legha Ansari Abbasali Khademi Seeram Ramakrishna |
| author_sort | Niloufar Abedi |
| collection | DOAJ |
| description | Oral and maxillofacial tissue defects caused by trauma, tumor reactions, congenital anomalies, ischemic diseases, infectious diseases, surgical resection, and odontogenic cysts present a formidable challenge for reconstruction. Tissue regeneration using functional biomaterials and cell therapy strategies has raised great concerns in the treatment of damaged tissue during the past few decades. However, during biomaterials implantation and cell transplantation, the production of excessive reactive oxygen species (ROS) may hinder tissue repair as it commonly causes severe tissue injuries leading to the cell damage. These products exist in form of oxidant molecules such as hydrogen peroxide, superoxide ions, hydroxyl radicals, and nitrogen oxide. These days, many scientists have focused on the application of ROS-scavenging components in the body during the tissue regeneration process. One of these scavenging components is antioxidants, which are beneficial materials for the treatment of damaged tissues and keeping tissues safe against free radicals. Antioxidants are divided into natural and synthetic sources. In the current review article, different antioxidant sources and their mechanism of action are discussed. The applications of antioxidants in the regeneration of oral and maxillofacial tissues, including hard tissues of cranial, alveolar bone, dental tissue, oral soft tissue (dental pulp, periodontal soft tissue), facial nerve, and cartilage tissues, are also highlighted in the following parts. |
| first_indexed | 2024-03-11T07:00:16Z |
| format | Article |
| id | doaj.art-21bea750307d40f2a8fdce23ccd927d2 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T07:00:16Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-21bea750307d40f2a8fdce23ccd927d22023-11-17T09:16:59ZengMDPI AGAntioxidants2076-39212023-02-0112359410.3390/antiox12030594Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the LiteratureNiloufar Abedi0Zahra Sadat Sajadi-Javan1Monireh Kouhi2Legha Ansari3Abbasali Khademi4Seeram Ramakrishna5Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, IranNosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, IranDental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, IranCellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia 57157-89400, IranDepartment of Endodontics, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, IranDepartment of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, SingaporeOral and maxillofacial tissue defects caused by trauma, tumor reactions, congenital anomalies, ischemic diseases, infectious diseases, surgical resection, and odontogenic cysts present a formidable challenge for reconstruction. Tissue regeneration using functional biomaterials and cell therapy strategies has raised great concerns in the treatment of damaged tissue during the past few decades. However, during biomaterials implantation and cell transplantation, the production of excessive reactive oxygen species (ROS) may hinder tissue repair as it commonly causes severe tissue injuries leading to the cell damage. These products exist in form of oxidant molecules such as hydrogen peroxide, superoxide ions, hydroxyl radicals, and nitrogen oxide. These days, many scientists have focused on the application of ROS-scavenging components in the body during the tissue regeneration process. One of these scavenging components is antioxidants, which are beneficial materials for the treatment of damaged tissues and keeping tissues safe against free radicals. Antioxidants are divided into natural and synthetic sources. In the current review article, different antioxidant sources and their mechanism of action are discussed. The applications of antioxidants in the regeneration of oral and maxillofacial tissues, including hard tissues of cranial, alveolar bone, dental tissue, oral soft tissue (dental pulp, periodontal soft tissue), facial nerve, and cartilage tissues, are also highlighted in the following parts.https://www.mdpi.com/2076-3921/12/3/594cranio-maxillofacialdentalreactive oxygen speciesantioxidantstissue regeneration |
| spellingShingle | Niloufar Abedi Zahra Sadat Sajadi-Javan Monireh Kouhi Legha Ansari Abbasali Khademi Seeram Ramakrishna Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature Antioxidants cranio-maxillofacial dental reactive oxygen species antioxidants tissue regeneration |
| title | Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature |
| title_full | Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature |
| title_fullStr | Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature |
| title_full_unstemmed | Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature |
| title_short | Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature |
| title_sort | antioxidant materials in oral and maxillofacial tissue regeneration a narrative review of the literature |
| topic | cranio-maxillofacial dental reactive oxygen species antioxidants tissue regeneration |
| url | https://www.mdpi.com/2076-3921/12/3/594 |
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