Introduction of Androgen Receptor Targeting shRNA Inhibits Tumor Growth in Patient-Derived Prostate Cancer Xenografts

Introduction of Androgen Receptor Targeting shRNA Inhibits Tumor Growth in Patient-Derived Prostate Cancer Xenografts

Patient-derived xenograft (PDX) models have been established as important preclinical cancer models, overcoming some of the limitations associated with the use of cancer cell lines. The utility of prostate cancer PDX models has been limited by an inability to genetically manipulate them in vivo and...

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Bibliographic Details
Main Authors: Patrick B. Thomas, Saeid Alinezhad, Andre Joshi, Katrina Sweeney, Brian W. C. Tse, Gregor Tevz, Stephen McPherson, Colleen C. Nelson, Elizabeth D. Williams, Ian Vela
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Current Oncology
Subjects:
prostate cancer
organoids
precision medicine
patient-derived xenograft
androgen receptor
Online Access:https://www.mdpi.com/1718-7729/30/11/683

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