Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer
Thyroid carcinoma (TC) is the most common malignancy of endocrine organs with an increasing incidence in industrialized countries. The majority of TC are characterized by a good prognosis, even though cases with aggressive forms not cured by standard therapies are also present. Moreover, target ther...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/1/129 |
| _version_ | 1797711154540183552 |
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| author | Maria Chiara Anania Tiziana Di Marco Mara Mazzoni Angela Greco |
| author_facet | Maria Chiara Anania Tiziana Di Marco Mara Mazzoni Angela Greco |
| author_sort | Maria Chiara Anania |
| collection | DOAJ |
| description | Thyroid carcinoma (TC) is the most common malignancy of endocrine organs with an increasing incidence in industrialized countries. The majority of TC are characterized by a good prognosis, even though cases with aggressive forms not cured by standard therapies are also present. Moreover, target therapies have led to low rates of partial response and prompted the emergence of resistance, indicating that new therapies are needed. In this review, we summarize current literature about the non-oncogene addiction (NOA) concept, which indicates that cancer cells, at variance with normal cells, rely on the activity of genes, usually not mutated or aberrantly expressed, essential for coping with the transformed phenotype. We highlight the potential of non-oncogenes as a point of intervention for cancer therapy in general, and present evidence for new putative non-oncogenes that are essential for TC survival and that may constitute attractive new therapeutic targets. |
| first_indexed | 2024-03-12T07:02:54Z |
| format | Article |
| id | doaj.art-21c183534bcf4cb4b2e6f8cf51d82088 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:02:54Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-21c183534bcf4cb4b2e6f8cf51d820882023-09-02T23:37:33ZengMDPI AGCancers2072-66942020-01-0112112910.3390/cancers12010129cancers12010129Targeting Non-Oncogene Addiction: Focus on Thyroid CancerMaria Chiara Anania0Tiziana Di Marco1Mara Mazzoni2Angela Greco3Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyMolecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyMolecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyMolecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyThyroid carcinoma (TC) is the most common malignancy of endocrine organs with an increasing incidence in industrialized countries. The majority of TC are characterized by a good prognosis, even though cases with aggressive forms not cured by standard therapies are also present. Moreover, target therapies have led to low rates of partial response and prompted the emergence of resistance, indicating that new therapies are needed. In this review, we summarize current literature about the non-oncogene addiction (NOA) concept, which indicates that cancer cells, at variance with normal cells, rely on the activity of genes, usually not mutated or aberrantly expressed, essential for coping with the transformed phenotype. We highlight the potential of non-oncogenes as a point of intervention for cancer therapy in general, and present evidence for new putative non-oncogenes that are essential for TC survival and that may constitute attractive new therapeutic targets.https://www.mdpi.com/2072-6694/12/1/129non-oncogene addictionthyroid cancerfunctional screeningnon-oncogenestumor vulnerabilitiestherapeutic targets |
| spellingShingle | Maria Chiara Anania Tiziana Di Marco Mara Mazzoni Angela Greco Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer Cancers non-oncogene addiction thyroid cancer functional screening non-oncogenes tumor vulnerabilities therapeutic targets |
| title | Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer |
| title_full | Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer |
| title_fullStr | Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer |
| title_full_unstemmed | Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer |
| title_short | Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer |
| title_sort | targeting non oncogene addiction focus on thyroid cancer |
| topic | non-oncogene addiction thyroid cancer functional screening non-oncogenes tumor vulnerabilities therapeutic targets |
| url | https://www.mdpi.com/2072-6694/12/1/129 |
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