Atractylenolide I Ameliorates Acetaminophen-Induced Acute Liver Injury via the TLR4/MAPKs/NF-κB Signaling Pathways

Atractylenolide I Ameliorates Acetaminophen-Induced Acute Liver Injury via the TLR4/MAPKs/NF-κB Signaling Pathways

Background: Acetaminophen (APAP) overdose results in the production of reactive oxygen species (ROS), induces hepatocyte necrosis, and leads to acute liver failure. Atractylenolide I (AO-I), a phytochemical found in Atractylodes macrocephala Koidz, is known to exhibit antioxidant activity. However,...

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Bibliographic Details
Main Authors: Zhongyan Du, Zhimei Ma, Shanglei Lai, Qinchao Ding, Ziyi Hu, Wenwen Yang, Qianyu Qian, Linwensi Zhu, Xiaobing Dou, Songtao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
atractylenolide I
acetaminophen
liver injury
TLR4/MAPKs/NF-κB
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.797499/full

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