Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis
Background: Several studies have investigated the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-12-01
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| Series: | Chronic Diseases and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095882X17300105 |
| _version_ | 1828334648750505984 |
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| author | Chao Han Xi-Kun Han Fang-Chao Liu Jian-Feng Huang |
| author_facet | Chao Han Xi-Kun Han Fang-Chao Liu Jian-Feng Huang |
| author_sort | Chao Han |
| collection | DOAJ |
| description | Background: Several studies have investigated the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relationship in the general population of different ethnicities.
Methods: We searched PubMed, Embase, Web of Science, Wanfang Database, and CNKI to identify eligible studies. Random-effect models were applied to estimate the pooled odds ratio (OR) with a 95% confidence interval (CI), regardless of between-study heterogeneity.
Results: A total of 13 studies with 1966 cases and 6129 controls were included in this meta-analysis. The pooled ORs for the association between ACE I/D polymorphism and PVD risk were not statistically significant in the overall population under all genetic models. In further ethnicity-stratified analyses, we found a statistically significant association of ACE I/D polymorphism with PVD susceptibility in Asians under most models. However, the association among Caucasians did not reach statistical significance.
Conclusion: ACE I/D polymorphism might be associated with susceptibility to PVD in the Asian population, but there was no clear evidence indicating a similar significant relationship among Caucasians. |
| first_indexed | 2024-04-13T21:35:54Z |
| format | Article |
| id | doaj.art-21c3504d31424ed78121ea17f2835d36 |
| institution | Directory Open Access Journal |
| issn | 2095-882X |
| language | English |
| last_indexed | 2024-04-13T21:35:54Z |
| publishDate | 2017-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Chronic Diseases and Translational Medicine |
| spelling | doaj.art-21c3504d31424ed78121ea17f2835d362022-12-22T02:28:58ZengWileyChronic Diseases and Translational Medicine2095-882X2017-12-013423024110.1016/j.cdtm.2017.07.002Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysisChao HanXi-Kun HanFang-Chao LiuJian-Feng HuangBackground: Several studies have investigated the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relationship in the general population of different ethnicities. Methods: We searched PubMed, Embase, Web of Science, Wanfang Database, and CNKI to identify eligible studies. Random-effect models were applied to estimate the pooled odds ratio (OR) with a 95% confidence interval (CI), regardless of between-study heterogeneity. Results: A total of 13 studies with 1966 cases and 6129 controls were included in this meta-analysis. The pooled ORs for the association between ACE I/D polymorphism and PVD risk were not statistically significant in the overall population under all genetic models. In further ethnicity-stratified analyses, we found a statistically significant association of ACE I/D polymorphism with PVD susceptibility in Asians under most models. However, the association among Caucasians did not reach statistical significance. Conclusion: ACE I/D polymorphism might be associated with susceptibility to PVD in the Asian population, but there was no clear evidence indicating a similar significant relationship among Caucasians.http://www.sciencedirect.com/science/article/pii/S2095882X17300105Peripheral vascular diseaseAngiotensin-converting enzymeInsertion/deletion polymorphismMeta-analysis |
| spellingShingle | Chao Han Xi-Kun Han Fang-Chao Liu Jian-Feng Huang Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis Chronic Diseases and Translational Medicine Peripheral vascular disease Angiotensin-converting enzyme Insertion/deletion polymorphism Meta-analysis |
| title | Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis |
| title_full | Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis |
| title_fullStr | Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis |
| title_full_unstemmed | Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis |
| title_short | Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis |
| title_sort | ethnic differences in the association between angiotensin converting enzyme gene insertion deletion polymorphism and peripheral vascular disease a meta analysis |
| topic | Peripheral vascular disease Angiotensin-converting enzyme Insertion/deletion polymorphism Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2095882X17300105 |
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