The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity
Trained immunity describes the ability of innate immune cells to form immunological memories of prior encounters with pathogens. Recollection of these memories during a secondary encounter manifests a broadly enhanced inflammatory response characterized by the increased transcription of innate immun...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.03184/full |
| _version_ | 1818409146928594944 |
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| author | Ezio T. Fok Ezio T. Fok Laurianne Davignon Stephanie Fanucchi Stephanie Fanucchi Musa M. Mhlanga Musa M. Mhlanga |
| author_facet | Ezio T. Fok Ezio T. Fok Laurianne Davignon Stephanie Fanucchi Stephanie Fanucchi Musa M. Mhlanga Musa M. Mhlanga |
| author_sort | Ezio T. Fok |
| collection | DOAJ |
| description | Trained immunity describes the ability of innate immune cells to form immunological memories of prior encounters with pathogens. Recollection of these memories during a secondary encounter manifests a broadly enhanced inflammatory response characterized by the increased transcription of innate immune genes. Despite this phenomenon having been described over a decade ago, our understanding of the molecular mechanisms responsible for this phenotype is still incomplete. Here we present an overview of the molecular events that lead to training. For the first time, we highlight the mechanistic role of a novel class of long non-coding RNAs (lncRNAs) in the establishment and maintenance of discrete, long lasting epigenetic modifications that are causal to the trained immune response. This recent insight fills in significant gaps in our understanding of trained immunity and reveals novel ways to exploit trained immunity for therapeutic purposes. |
| first_indexed | 2024-12-14T09:55:00Z |
| format | Article |
| id | doaj.art-21c64b4163184cc9a71445c32d3a101e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T09:55:00Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-21c64b4163184cc9a71445c32d3a101e2022-12-21T23:07:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-01-01910.3389/fimmu.2018.03184429173The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained ImmunityEzio T. Fok0Ezio T. Fok1Laurianne Davignon2Stephanie Fanucchi3Stephanie Fanucchi4Musa M. Mhlanga5Musa M. Mhlanga6Division of Chemical, Systems & Synthetic Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South AfricaGene Expression and Biophysics Group, ERA, CSIR Biosciences, Pretoria, South AfricaDivision of Chemical, Systems & Synthetic Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South AfricaDivision of Chemical, Systems & Synthetic Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South AfricaGene Expression and Biophysics Group, ERA, CSIR Biosciences, Pretoria, South AfricaDivision of Chemical, Systems & Synthetic Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South AfricaGene Expression and Biophysics Unit, Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon, PortugalTrained immunity describes the ability of innate immune cells to form immunological memories of prior encounters with pathogens. Recollection of these memories during a secondary encounter manifests a broadly enhanced inflammatory response characterized by the increased transcription of innate immune genes. Despite this phenomenon having been described over a decade ago, our understanding of the molecular mechanisms responsible for this phenotype is still incomplete. Here we present an overview of the molecular events that lead to training. For the first time, we highlight the mechanistic role of a novel class of long non-coding RNAs (lncRNAs) in the establishment and maintenance of discrete, long lasting epigenetic modifications that are causal to the trained immune response. This recent insight fills in significant gaps in our understanding of trained immunity and reveals novel ways to exploit trained immunity for therapeutic purposes.https://www.frontiersin.org/article/10.3389/fimmu.2018.03184/fulltrained immunityepigeneticsmetabolismlong non-codinginflammationnuclear architecture |
| spellingShingle | Ezio T. Fok Ezio T. Fok Laurianne Davignon Stephanie Fanucchi Stephanie Fanucchi Musa M. Mhlanga Musa M. Mhlanga The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity Frontiers in Immunology trained immunity epigenetics metabolism long non-coding inflammation nuclear architecture |
| title | The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity |
| title_full | The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity |
| title_fullStr | The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity |
| title_full_unstemmed | The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity |
| title_short | The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity |
| title_sort | lncrna connection between cellular metabolism and epigenetics in trained immunity |
| topic | trained immunity epigenetics metabolism long non-coding inflammation nuclear architecture |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.03184/full |
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