Mild oxidative stress protects against chemotherapy-induced hair loss
Chemotherapy induces hair loss in most cancer patients who undergo treatment, which causes them significant psychosocial trauma. Scalp cooling has demonstrated some efficacy in attenuating chemotherapy-induced alopecia, but response rate varies between patients and chemotherapy class. Here, we showc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1078916/full |
| _version_ | 1828067580079767552 |
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| author | Yusheng Zhang Joaquin J. Jimenez |
| author_facet | Yusheng Zhang Joaquin J. Jimenez |
| author_sort | Yusheng Zhang |
| collection | DOAJ |
| description | Chemotherapy induces hair loss in most cancer patients who undergo treatment, which causes them significant psychosocial trauma. Scalp cooling has demonstrated some efficacy in attenuating chemotherapy-induced alopecia, but response rate varies between patients and chemotherapy class. Here, we showcase in rats a proof-of-concept treatment of using subcutaneous hydrogen peroxide and cumene hydroperoxide injections to provide total protection from hair loss against multiple classes of chemotherapy. We found that subcutaneous peroxides induce cell cycle arrest via P53 activation, thereby protecting hair follicles from the cytotoxic effects of chemotherapy on actively dividing cells. This treatment represents a highly effective and accessible way for cancer patients to maintain quality of life while undergoing treatment for cancer. |
| first_indexed | 2024-04-10T23:47:46Z |
| format | Article |
| id | doaj.art-21c6d31ceae745889e66f2eb9b596ba0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T23:47:46Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-21c6d31ceae745889e66f2eb9b596ba02023-01-10T21:49:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10789161078916Mild oxidative stress protects against chemotherapy-induced hair lossYusheng ZhangJoaquin J. JimenezChemotherapy induces hair loss in most cancer patients who undergo treatment, which causes them significant psychosocial trauma. Scalp cooling has demonstrated some efficacy in attenuating chemotherapy-induced alopecia, but response rate varies between patients and chemotherapy class. Here, we showcase in rats a proof-of-concept treatment of using subcutaneous hydrogen peroxide and cumene hydroperoxide injections to provide total protection from hair loss against multiple classes of chemotherapy. We found that subcutaneous peroxides induce cell cycle arrest via P53 activation, thereby protecting hair follicles from the cytotoxic effects of chemotherapy on actively dividing cells. This treatment represents a highly effective and accessible way for cancer patients to maintain quality of life while undergoing treatment for cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.1078916/fullchemotherapy-induced hair losschemotherapy-induced alopeciahair loss (alopecia)canceralopecia preventionprotection against hair loss |
| spellingShingle | Yusheng Zhang Joaquin J. Jimenez Mild oxidative stress protects against chemotherapy-induced hair loss Frontiers in Oncology chemotherapy-induced hair loss chemotherapy-induced alopecia hair loss (alopecia) cancer alopecia prevention protection against hair loss |
| title | Mild oxidative stress protects against chemotherapy-induced hair loss |
| title_full | Mild oxidative stress protects against chemotherapy-induced hair loss |
| title_fullStr | Mild oxidative stress protects against chemotherapy-induced hair loss |
| title_full_unstemmed | Mild oxidative stress protects against chemotherapy-induced hair loss |
| title_short | Mild oxidative stress protects against chemotherapy-induced hair loss |
| title_sort | mild oxidative stress protects against chemotherapy induced hair loss |
| topic | chemotherapy-induced hair loss chemotherapy-induced alopecia hair loss (alopecia) cancer alopecia prevention protection against hair loss |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1078916/full |
| work_keys_str_mv | AT yushengzhang mildoxidativestressprotectsagainstchemotherapyinducedhairloss AT joaquinjjimenez mildoxidativestressprotectsagainstchemotherapyinducedhairloss |