Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay
ABSTRACT: Hypotrichosis congenita is a significant disease in Hereford cattle in Uruguay and has been reported worldwide. However, the causal mutation KRT71 has only been recently identified. This communication describes the clinical, histopathological, trichographic, and genetic findings of KRT71-h...
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| Format: | Article |
| Language: | English |
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Colégio Brasileiro de Patologia Animal (CBPA)
2023-10-01
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| Series: | Pesquisa Veterinária Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2023000100234&lng=en&tlng=en |
| _version_ | 1827191661719977984 |
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| author | Agustín Romero-Benavente Carolina Briano-Rodriguez Fernando Dutra-Quintela |
| author_facet | Agustín Romero-Benavente Carolina Briano-Rodriguez Fernando Dutra-Quintela |
| author_sort | Agustín Romero-Benavente |
| collection | DOAJ |
| description | ABSTRACT: Hypotrichosis congenita is a significant disease in Hereford cattle in Uruguay and has been reported worldwide. However, the causal mutation KRT71 has only been recently identified. This communication describes the clinical, histopathological, trichographic, and genetic findings of KRT71-hypotrichosis congenita observed in Hereford calves from two commercial farms. Five affected newborn calves, born in a herd of 15 purebred Polled HF cows, were examined in Farm 1, and one weaned calf in Farm 2. Skin biopsies for histopathology, hair samples for trichogram, and blood samples for genotyping were obtained from affected and control calves and the sire bull and mother cows. Affected animals exhibited a light brown coat with sparse, thin, curly or woolly haircoat. Hypotrichotic skin was dry, erythematous, and scaly. Trichogram analysis revealed thin, fragmented, curly hairs with irregular macro-melanosome groups. The main histopathological findings included marked follicular dysplasia with vacuolation, abnormally large trichohyaline granules in Huxley’s layer, and multiple melanin aggregates in hair fragments, matrix cells, and dysplastic follicles. There were no histological lesions of dermatitis. DNA analysis confirmed that hypotrichotic calves were homozygous for the KRT71 mutation, while one control calf, the bull, and cows in Farm 2 were heterozygous carriers. In conclusion, hypotrichosis congenita in Hereford cattle due to the KRT71 mutation is a color dilution follicular dysplasia. |
| first_indexed | 2024-03-11T19:05:01Z |
| format | Article |
| id | doaj.art-21c87571b07544e7a83ee3c7603ec711 |
| institution | Directory Open Access Journal |
| issn | 1678-5150 |
| language | English |
| last_indexed | 2025-03-21T08:29:18Z |
| publishDate | 2023-10-01 |
| publisher | Colégio Brasileiro de Patologia Animal (CBPA) |
| record_format | Article |
| series | Pesquisa Veterinária Brasileira |
| spelling | doaj.art-21c87571b07544e7a83ee3c7603ec7112024-07-12T12:10:17ZengColégio Brasileiro de Patologia Animal (CBPA)Pesquisa Veterinária Brasileira1678-51502023-10-014310.1590/1678-5150-pvb-7327Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in UruguayAgustín Romero-Benaventehttps://orcid.org/0000-0001-5110-1846Carolina Briano-Rodriguezhttps://orcid.org/0000-0002-5295-9550Fernando Dutra-Quintelahttps://orcid.org/0000-0003-4886-9429ABSTRACT: Hypotrichosis congenita is a significant disease in Hereford cattle in Uruguay and has been reported worldwide. However, the causal mutation KRT71 has only been recently identified. This communication describes the clinical, histopathological, trichographic, and genetic findings of KRT71-hypotrichosis congenita observed in Hereford calves from two commercial farms. Five affected newborn calves, born in a herd of 15 purebred Polled HF cows, were examined in Farm 1, and one weaned calf in Farm 2. Skin biopsies for histopathology, hair samples for trichogram, and blood samples for genotyping were obtained from affected and control calves and the sire bull and mother cows. Affected animals exhibited a light brown coat with sparse, thin, curly or woolly haircoat. Hypotrichotic skin was dry, erythematous, and scaly. Trichogram analysis revealed thin, fragmented, curly hairs with irregular macro-melanosome groups. The main histopathological findings included marked follicular dysplasia with vacuolation, abnormally large trichohyaline granules in Huxley’s layer, and multiple melanin aggregates in hair fragments, matrix cells, and dysplastic follicles. There were no histological lesions of dermatitis. DNA analysis confirmed that hypotrichotic calves were homozygous for the KRT71 mutation, while one control calf, the bull, and cows in Farm 2 were heterozygous carriers. In conclusion, hypotrichosis congenita in Hereford cattle due to the KRT71 mutation is a color dilution follicular dysplasia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2023000100234&lng=en&tlng=enHypotrichosis congenitacoat-color dilutionHereford cattlesemi-hairlessnessKRT71 mutation |
| spellingShingle | Agustín Romero-Benavente Carolina Briano-Rodriguez Fernando Dutra-Quintela Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay Pesquisa Veterinária Brasileira Hypotrichosis congenita coat-color dilution Hereford cattle semi-hairlessness KRT71 mutation |
| title | Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay |
| title_full | Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay |
| title_fullStr | Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay |
| title_full_unstemmed | Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay |
| title_short | Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay |
| title_sort | hypotrichosis congenita krt71 mutation in hereford cattle in uruguay |
| topic | Hypotrichosis congenita coat-color dilution Hereford cattle semi-hairlessness KRT71 mutation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2023000100234&lng=en&tlng=en |
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