Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells

Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells

We previously showed that in polarized Madin–Darby canine kidney (MDCK) cells, aquaporin-2 (AQP2) is continuously targeted to the basolateral plasma membrane from which it is rapidly retrieved by clathrin-mediated endocytosis. It then undertakes microtubule-dependent transcytosis toward the apical p...

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Bibliographic Details
Main Authors: Richard Bouley, Naofumi Yui, Abby Terlouw, Pui W. Cheung, Dennis Brown
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
water-channel
aquaporin
LLC-PK1 kidney cells
forskolin
vasopressin
Online Access:https://www.mdpi.com/2073-4409/9/4/1057

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