Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis
ABSTRACTThis study aims to conduct a bibliometric analysis, employing visualization tools to examine literature pertaining to tumor immune evasion related to anti-CTLA-4 and anti-PD-1/PD-L1 therapy from 1999 to 2022. A special emphasis is placed on the interplay between tumor microenvironment, signa...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2318815 |
| _version_ | 1797291471771009024 |
|---|---|
| author | Yi Huang Zhijian Chen Gang Shen Shuogui Fang Junjiong Zheng Zepai Chi Yuanfeng Zhang Yitong Zou Qinghua Gan Chengxiao Liao Yuhui Yao Jianqiu Kong Xinxiang Fan |
| author_facet | Yi Huang Zhijian Chen Gang Shen Shuogui Fang Junjiong Zheng Zepai Chi Yuanfeng Zhang Yitong Zou Qinghua Gan Chengxiao Liao Yuhui Yao Jianqiu Kong Xinxiang Fan |
| author_sort | Yi Huang |
| collection | DOAJ |
| description | ABSTRACTThis study aims to conduct a bibliometric analysis, employing visualization tools to examine literature pertaining to tumor immune evasion related to anti-CTLA-4 and anti-PD-1/PD-L1 therapy from 1999 to 2022. A special emphasis is placed on the interplay between tumor microenvironment, signaling pathways, immune cells and immune evasion, with data sourced from the Web of Science core collection (WoSCC). Advanced tools, including VOSviewer, Citespace, and Scimago Graphica, were utilized to analyze various parameters, such as co-authorship/co-citation patterns, regional contributions, journal preferences, keyword co-occurrences, and significant citation bursts. Out of 4778 publications reviewed, there was a marked increase in research focusing on immune evasion, with bladder cancer being notably prominent. Geographically, China, the USA, and Japan were the leading contributors. Prestigious institutions like MD Anderson Cancer Center, Harvard Medical School, Fudan University, and Sun Yat Sen University emerged as major players. Renowned journals in this domain included Frontiers in Immunology, Cancers, and Frontiers in Oncology. Ehen LP and Wang W were identified as prolific authors on this topic, while Topalian SL stood out as one of the most cited. Research current situation is notably pivoting toward challenges like immunotherapy resistance and the intricate signaling pathways driving drug resistance. This bibliometric study seeks to provide a comprehensive overview of past and current research trends, emphasizing the potential role of tumor microenvironment, signaling pathways and immune cells in the context of immune checkpoint inhibitors (ICIs) and tumor immune evasion. |
| first_indexed | 2024-03-07T19:37:21Z |
| format | Article |
| id | doaj.art-21c9f8870bdf41369ec5529eb545656b |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-07T19:37:21Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-21c9f8870bdf41369ec5529eb545656b2024-02-29T07:58:00ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2318815Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysisYi Huang0Zhijian Chen1Gang Shen2Shuogui Fang3Junjiong Zheng4Zepai Chi5Yuanfeng Zhang6Yitong Zou7Qinghua Gan8Chengxiao Liao9Yuhui Yao10Jianqiu Kong11Xinxiang Fan12Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaDepartment of Urology, DUSHU Lake Hospital Affiliated to Soochow University, Suzhou, ChinaDepartment of Radiotherapy, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaDepartment of urology, Shantou Central Hospital, Shantou, ChinaDepartment of urology, Shantou Central Hospital, Shantou, ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. ChinaABSTRACTThis study aims to conduct a bibliometric analysis, employing visualization tools to examine literature pertaining to tumor immune evasion related to anti-CTLA-4 and anti-PD-1/PD-L1 therapy from 1999 to 2022. A special emphasis is placed on the interplay between tumor microenvironment, signaling pathways, immune cells and immune evasion, with data sourced from the Web of Science core collection (WoSCC). Advanced tools, including VOSviewer, Citespace, and Scimago Graphica, were utilized to analyze various parameters, such as co-authorship/co-citation patterns, regional contributions, journal preferences, keyword co-occurrences, and significant citation bursts. Out of 4778 publications reviewed, there was a marked increase in research focusing on immune evasion, with bladder cancer being notably prominent. Geographically, China, the USA, and Japan were the leading contributors. Prestigious institutions like MD Anderson Cancer Center, Harvard Medical School, Fudan University, and Sun Yat Sen University emerged as major players. Renowned journals in this domain included Frontiers in Immunology, Cancers, and Frontiers in Oncology. Ehen LP and Wang W were identified as prolific authors on this topic, while Topalian SL stood out as one of the most cited. Research current situation is notably pivoting toward challenges like immunotherapy resistance and the intricate signaling pathways driving drug resistance. This bibliometric study seeks to provide a comprehensive overview of past and current research trends, emphasizing the potential role of tumor microenvironment, signaling pathways and immune cells in the context of immune checkpoint inhibitors (ICIs) and tumor immune evasion.https://www.tandfonline.com/doi/10.1080/21645515.2024.2318815Immune checkpoint inhibitors (ICIs)PD-1/PD-L1CLTA-4immune evasionbibliometrics |
| spellingShingle | Yi Huang Zhijian Chen Gang Shen Shuogui Fang Junjiong Zheng Zepai Chi Yuanfeng Zhang Yitong Zou Qinghua Gan Chengxiao Liao Yuhui Yao Jianqiu Kong Xinxiang Fan Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis Human Vaccines & Immunotherapeutics Immune checkpoint inhibitors (ICIs) PD-1/PD-L1 CLTA-4 immune evasion bibliometrics |
| title | Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis |
| title_full | Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis |
| title_fullStr | Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis |
| title_full_unstemmed | Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis |
| title_short | Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis |
| title_sort | immune regulation and the tumor microenvironment in anti pd 1 pdl 1 and anti ctla 4 therapies for cancer immune evasion a bibliometric analysis |
| topic | Immune checkpoint inhibitors (ICIs) PD-1/PD-L1 CLTA-4 immune evasion bibliometrics |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2318815 |
| work_keys_str_mv | AT yihuang immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT zhijianchen immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT gangshen immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT shuoguifang immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT junjiongzheng immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT zepaichi immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT yuanfengzhang immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT yitongzou immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT qinghuagan immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT chengxiaoliao immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT yuhuiyao immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT jianqiukong immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis AT xinxiangfan immuneregulationandthetumormicroenvironmentinantipd1pdl1andantictla4therapiesforcancerimmuneevasionabibliometricanalysis |