The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism
Besides their main function for energy production in form of ATP in processes of oxidative phosphorylation (OxPhos), mitochondria perform many other important cellular functions and participate in various physiological processes that are congregated. For example, mitochondria are considered to be on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/10/1995 |
| _version_ | 1827651994766016512 |
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| author | Andrey V. Kuznetsov Raimund Margreiter Michael J. Ausserlechner Judith Hagenbuchner |
| author_facet | Andrey V. Kuznetsov Raimund Margreiter Michael J. Ausserlechner Judith Hagenbuchner |
| author_sort | Andrey V. Kuznetsov |
| collection | DOAJ |
| description | Besides their main function for energy production in form of ATP in processes of oxidative phosphorylation (OxPhos), mitochondria perform many other important cellular functions and participate in various physiological processes that are congregated. For example, mitochondria are considered to be one of the main sources of reactive oxygen species (ROS) and therefore they actively participate in the regulation of cellular redox and ROS signaling. These organelles also play a crucial role in Ca<sup>2+</sup> signaling and homeostasis. The mitochondrial OxPhos and their cellular functions are strongly cell/tissue specific and can be heterogeneous even within the same cell, due to the existence of mitochondrial subpopulations with distinct functional and structural properties. However, the interplay between different functions of mitochondria is not fully understood. The mitochondrial functions may change as a response to the changes in the cellular metabolism (signaling in). On the other hand, several factors and feedback signals from mitochondria may influence the entire cell physiology (signaling out). Numerous interactions between mitochondria and the rest of cell, various cytoskeletal proteins, endoplasmic reticulum (ER) and other cellular elements have been demonstrated, and these interactions could actively participate in the regulation of mitochondrial and cellular metabolism. This review highlights the important role of the interplay between mitochondrial and entire cell physiology, including signaling from and to mitochondria. |
| first_indexed | 2024-03-09T20:48:18Z |
| format | Article |
| id | doaj.art-21ca38e5741f4084b769740537985fe4 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:48:18Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-21ca38e5741f4084b769740537985fe42023-11-23T22:39:04ZengMDPI AGAntioxidants2076-39212022-10-011110199510.3390/antiox11101995The Complex Interplay between Mitochondria, ROS and Entire Cellular MetabolismAndrey V. Kuznetsov0Raimund Margreiter1Michael J. Ausserlechner2Judith Hagenbuchner3Department of Pediatrics I, Medical University of Innsbruck, A-6020 Innsbruck, AustriaDepartment of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, A-6020 Innsbruck, AustriaDepartment of Pediatrics I, Medical University of Innsbruck, A-6020 Innsbruck, AustriaDepartment of Pediatrics II, Medical University of Innsbruck, A-6020 Innsbruck, AustriaBesides their main function for energy production in form of ATP in processes of oxidative phosphorylation (OxPhos), mitochondria perform many other important cellular functions and participate in various physiological processes that are congregated. For example, mitochondria are considered to be one of the main sources of reactive oxygen species (ROS) and therefore they actively participate in the regulation of cellular redox and ROS signaling. These organelles also play a crucial role in Ca<sup>2+</sup> signaling and homeostasis. The mitochondrial OxPhos and their cellular functions are strongly cell/tissue specific and can be heterogeneous even within the same cell, due to the existence of mitochondrial subpopulations with distinct functional and structural properties. However, the interplay between different functions of mitochondria is not fully understood. The mitochondrial functions may change as a response to the changes in the cellular metabolism (signaling in). On the other hand, several factors and feedback signals from mitochondria may influence the entire cell physiology (signaling out). Numerous interactions between mitochondria and the rest of cell, various cytoskeletal proteins, endoplasmic reticulum (ER) and other cellular elements have been demonstrated, and these interactions could actively participate in the regulation of mitochondrial and cellular metabolism. This review highlights the important role of the interplay between mitochondrial and entire cell physiology, including signaling from and to mitochondria.https://www.mdpi.com/2076-3921/11/10/1995cellular metabolismmitochondriamitochondrial function/morphologymitochondrial interactionsredox stateROS |
| spellingShingle | Andrey V. Kuznetsov Raimund Margreiter Michael J. Ausserlechner Judith Hagenbuchner The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism Antioxidants cellular metabolism mitochondria mitochondrial function/morphology mitochondrial interactions redox state ROS |
| title | The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism |
| title_full | The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism |
| title_fullStr | The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism |
| title_full_unstemmed | The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism |
| title_short | The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism |
| title_sort | complex interplay between mitochondria ros and entire cellular metabolism |
| topic | cellular metabolism mitochondria mitochondrial function/morphology mitochondrial interactions redox state ROS |
| url | https://www.mdpi.com/2076-3921/11/10/1995 |
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