Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors

Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors

Background: The Transient Receptor Potential Melastatin member 4 (TRPM4) gene encodes a calcium-activated non-selective cation channel expressed in several tissues. Mutations in TRPM4 have been reported in patients with different types of cardiac conduction defects. It is also linked to immune respo...

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Bibliographic Details
Main Authors: Prakash Arullampalam, Barbara Preti, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sébastien Rougier, Hugues Abriel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
TRP channels
TRPM4
9-phenanthrol
comparative physiology
mouse models
patch-clamp
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.712354/full

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