Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States
Findings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these individuals when compared with age- and sex-matched...
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| Format: | Article |
| Language: | English |
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Advocate Aurora Health
2022-01-01
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| Series: | Journal of Patient-Centered Research and Reviews |
| Subjects: | |
| Online Access: | https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=1877&context=jpcrr |
| _version_ | 1811174059340201984 |
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| author | Anne Rivelli Veronica Fitzpatrick Danielle Wales Laura Chicoine Gengjie Jia Andrey Rzhetsky Brian Chicoine |
| author_facet | Anne Rivelli Veronica Fitzpatrick Danielle Wales Laura Chicoine Gengjie Jia Andrey Rzhetsky Brian Chicoine |
| author_sort | Anne Rivelli |
| collection | DOAJ |
| description | Findings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these individuals when compared with age- and sex-matched individuals without DS. This retrospective, descriptive study is a follow-up report documenting prevalence of 21 endocrine disorder conditions, across 28 years of data, from 6078 individuals with DS and 30,326 age- and sex-matched controls, abstracted from electronic medical records within a large integrated health system. Overall, individuals with DS experienced higher prevalence of adrenal insufficiency and Addison’s disease; thyroid disorders, including hypothyroidism, hyperthyroidism, Hashimoto’s disease, and Graves’ disease; prolactinoma/hyperprolactinemia; diabetes insipidus; type I diabetes mellitus; and gout. Conversely, those with DS had lower prevalence of polycystic ovary syndrome and type II diabetes mellitus. Many prevalences of endocrine conditions seen in individuals with DS significantly differ relative to their non-DS matched counterparts. These varied findings warrant further exploration into how screening for and treatment of endocrine conditions may need to be approached differently for individuals with DS. |
| first_indexed | 2024-04-10T17:57:00Z |
| format | Article |
| id | doaj.art-21d27177a4fc4a20a90b0451f57e31f3 |
| institution | Directory Open Access Journal |
| issn | 2330-0698 |
| language | English |
| last_indexed | 2024-04-10T17:57:00Z |
| publishDate | 2022-01-01 |
| publisher | Advocate Aurora Health |
| record_format | Article |
| series | Journal of Patient-Centered Research and Reviews |
| spelling | doaj.art-21d27177a4fc4a20a90b0451f57e31f32023-02-02T17:40:31ZengAdvocate Aurora HealthJournal of Patient-Centered Research and Reviews2330-06982022-01-0191707410.17294/2330-0698.1877Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United StatesAnne Rivelli0https://orcid.org/0000-0001-8676-5546Veronica Fitzpatrick1https://orcid.org/0000-0002-0509-3475Danielle Wales2https://orcid.org/0000-0002-4843-7960Laura Chicoine3Gengjie Jia4https://orcid.org/0000-0002-3020-3592Andrey Rzhetsky5https://orcid.org/0000-0001-6959-7405Brian Chicoine6https://orcid.org/0000-0002-1520-3893Advocate Aurora Research Institute, Advocate Aurora Health, Downers Grove, ILAdvocate Aurora Research Institute, Advocate Aurora Health, Downers Grove, ILRosalind Franklin University of Medicine and Science, North Chicago, ILAdvocate Medical Group Adult Down Syndrome Center, Advocate Aurora Health, Park Ridge, ILUniversity of Chicago, Chicago, ILUniversity of Chicago, Chicago, ILAdvocate Medical Group Adult Down Syndrome Center, Advocate Aurora Health, Park Ridge, ILFindings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these individuals when compared with age- and sex-matched individuals without DS. This retrospective, descriptive study is a follow-up report documenting prevalence of 21 endocrine disorder conditions, across 28 years of data, from 6078 individuals with DS and 30,326 age- and sex-matched controls, abstracted from electronic medical records within a large integrated health system. Overall, individuals with DS experienced higher prevalence of adrenal insufficiency and Addison’s disease; thyroid disorders, including hypothyroidism, hyperthyroidism, Hashimoto’s disease, and Graves’ disease; prolactinoma/hyperprolactinemia; diabetes insipidus; type I diabetes mellitus; and gout. Conversely, those with DS had lower prevalence of polycystic ovary syndrome and type II diabetes mellitus. Many prevalences of endocrine conditions seen in individuals with DS significantly differ relative to their non-DS matched counterparts. These varied findings warrant further exploration into how screening for and treatment of endocrine conditions may need to be approached differently for individuals with DS.https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=1877&context=jpcrrdown syndromeprevalenceendocrine diseasesthyroid disorderdiabetes mellitusadrenal insufficiency |
| spellingShingle | Anne Rivelli Veronica Fitzpatrick Danielle Wales Laura Chicoine Gengjie Jia Andrey Rzhetsky Brian Chicoine Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States Journal of Patient-Centered Research and Reviews down syndrome prevalence endocrine diseases thyroid disorder diabetes mellitus adrenal insufficiency |
| title | Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States |
| title_full | Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States |
| title_fullStr | Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States |
| title_full_unstemmed | Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States |
| title_short | Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States |
| title_sort | prevalence of endocrine disorders among 6078 individuals with down syndrome in the united states |
| topic | down syndrome prevalence endocrine diseases thyroid disorder diabetes mellitus adrenal insufficiency |
| url | https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=1877&context=jpcrr |
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