A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery
Background: Blood loss and problems associated with blood transfusion in burn wound excision is a major challenge a surgeon has to face. Topical application of antifibrinolytics has been used in many surgical fields. This study was conducted to assess the reduction of blood loss in burn wound excisi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Marine Medical Society |
| Subjects: | |
| Online Access: | http://www.marinemedicalsociety.in/article.asp?issn=0975-3605;year=2021;volume=23;issue=2;spage=129;epage=134;aulast=Mohan |
| _version_ | 1818738955634343936 |
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| author | Amitabh Mohan G Vishwanath Nagamahendran Rajendran |
| author_facet | Amitabh Mohan G Vishwanath Nagamahendran Rajendran |
| author_sort | Amitabh Mohan |
| collection | DOAJ |
| description | Background: Blood loss and problems associated with blood transfusion in burn wound excision is a major challenge a surgeon has to face. Topical application of antifibrinolytics has been used in many surgical fields. This study was conducted to assess the reduction of blood loss in burn wound excision by topical application of tranexamic acid. Materials and Methods: This Prospective observational study was conducted in a tertiary care hospital between February 2018 and May 2019. Results: In this study, we observe that by adding 0.5% tranexamic acid to 1 in 200,000 adrenalin topical solution, blood loss can be reduced while burns excision and skin grafting. In this study, after the application of tranexamic acid, the average blood loss per unit area reduced by 36% with significant P < 0.05. Conclusions: The use of tranexamic acid is effective and safe to use for topical use in concentration of 0.5% for reduction of blood loss in burn wound excision. However, further study with larger study group, should be done to confirm the findings of this study and further authenticating the results. |
| first_indexed | 2024-12-18T01:17:10Z |
| format | Article |
| id | doaj.art-21d2886c98444f36870c0a45830c9b18 |
| institution | Directory Open Access Journal |
| issn | 0975-3605 |
| language | English |
| last_indexed | 2024-12-18T01:17:10Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Marine Medical Society |
| spelling | doaj.art-21d2886c98444f36870c0a45830c9b182022-12-21T21:25:56ZengWolters Kluwer Medknow PublicationsJournal of Marine Medical Society0975-36052021-01-0123212913410.4103/jmms.jmms_25_20A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgeryAmitabh MohanG VishwanathNagamahendran RajendranBackground: Blood loss and problems associated with blood transfusion in burn wound excision is a major challenge a surgeon has to face. Topical application of antifibrinolytics has been used in many surgical fields. This study was conducted to assess the reduction of blood loss in burn wound excision by topical application of tranexamic acid. Materials and Methods: This Prospective observational study was conducted in a tertiary care hospital between February 2018 and May 2019. Results: In this study, we observe that by adding 0.5% tranexamic acid to 1 in 200,000 adrenalin topical solution, blood loss can be reduced while burns excision and skin grafting. In this study, after the application of tranexamic acid, the average blood loss per unit area reduced by 36% with significant P < 0.05. Conclusions: The use of tranexamic acid is effective and safe to use for topical use in concentration of 0.5% for reduction of blood loss in burn wound excision. However, further study with larger study group, should be done to confirm the findings of this study and further authenticating the results.http://www.marinemedicalsociety.in/article.asp?issn=0975-3605;year=2021;volume=23;issue=2;spage=129;epage=134;aulast=Mohanburn wound injuryexcision in burnstranexamic acid |
| spellingShingle | Amitabh Mohan G Vishwanath Nagamahendran Rajendran A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery Journal of Marine Medical Society burn wound injury excision in burns tranexamic acid |
| title | A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery |
| title_full | A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery |
| title_fullStr | A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery |
| title_full_unstemmed | A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery |
| title_short | A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery |
| title_sort | study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery |
| topic | burn wound injury excision in burns tranexamic acid |
| url | http://www.marinemedicalsociety.in/article.asp?issn=0975-3605;year=2021;volume=23;issue=2;spage=129;epage=134;aulast=Mohan |
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