Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), a progressive fibrosing lung condition is a ther-apeutic medical challenge. The etiopathogenesis of IPF is complicated and hitherto not adequately understood. However, the concept, of late, is shifting from fibrosis as a result of inflammation to a mechanism of p...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2007-01-01
|
| Series: | Lung India |
| Subjects: | |
| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2007;volume=24;issue=2;spage=61;epage=65;aulast=Bhattacharyya |
| _version_ | 1830274266227015680 |
|---|---|
| author | Bhattacharyya P Acharya D Roychowdhury S |
| author_facet | Bhattacharyya P Acharya D Roychowdhury S |
| author_sort | Bhattacharyya P |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis (IPF), a progressive fibrosing lung condition is a ther-apeutic medical challenge. The etiopathogenesis of IPF is complicated and hitherto not adequately understood. However, the concept, of late, is shifting from fibrosis as a result of inflammation to a mechanism of primarily dysregulated fibrogenesis. A class of enzymes called matrix metallo proteinases (MMPs) appear important in the pathogenesis of IPF. The heightened activity of MMPs are derived out of an imbalance between them (MMPs) and their tissue inhibitors (TIMPs). This leads to breakdown of interstitial matrix and triggering of certain growth factors which play an important mechanistic role in the pathogenesis of IPF. Understanding of the role of MMPs in pathogenesis of IPF may open up a new horizon of therapeutic intervention of the desease. |
| first_indexed | 2024-12-19T00:00:36Z |
| format | Article |
| id | doaj.art-21d524c4f86e43d688132ad8d6e70e98 |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-12-19T00:00:36Z |
| publishDate | 2007-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-21d524c4f86e43d688132ad8d6e70e982022-12-21T20:46:28ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2007-01-012426165Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosisBhattacharyya PAcharya DRoychowdhury SIdiopathic pulmonary fibrosis (IPF), a progressive fibrosing lung condition is a ther-apeutic medical challenge. The etiopathogenesis of IPF is complicated and hitherto not adequately understood. However, the concept, of late, is shifting from fibrosis as a result of inflammation to a mechanism of primarily dysregulated fibrogenesis. A class of enzymes called matrix metallo proteinases (MMPs) appear important in the pathogenesis of IPF. The heightened activity of MMPs are derived out of an imbalance between them (MMPs) and their tissue inhibitors (TIMPs). This leads to breakdown of interstitial matrix and triggering of certain growth factors which play an important mechanistic role in the pathogenesis of IPF. Understanding of the role of MMPs in pathogenesis of IPF may open up a new horizon of therapeutic intervention of the desease.http://www.lungindia.com/article.asp?issn=0970-2113;year=2007;volume=24;issue=2;spage=61;epage=65;aulast=BhattacharyyaPulmonary fibrosismatrix metalloproteinases. |
| spellingShingle | Bhattacharyya P Acharya D Roychowdhury S Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis Lung India Pulmonary fibrosis matrix metalloproteinases. |
| title | Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis |
| title_full | Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis |
| title_fullStr | Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis |
| title_full_unstemmed | Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis |
| title_short | Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis |
| title_sort | role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis |
| topic | Pulmonary fibrosis matrix metalloproteinases. |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2007;volume=24;issue=2;spage=61;epage=65;aulast=Bhattacharyya |
| work_keys_str_mv | AT bhattacharyyap roleofmatrixmetalloproteinasesinthepathophysiologyofidiopathicpulmonaryfibrosis AT acharyad roleofmatrixmetalloproteinasesinthepathophysiologyofidiopathicpulmonaryfibrosis AT roychowdhurys roleofmatrixmetalloproteinasesinthepathophysiologyofidiopathicpulmonaryfibrosis |