Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat
Introduction We tested whether normal-weight obesity might be associated with weight trajectories, body composition and metabolic traits.Research design and methods Body size trajectory since birth, body composition at age 20 years and metabolic traits were compared cross-sectionally among normal-we...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-11-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/10/6/e003045.full |
| _version_ | 1797787890684526592 |
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| author | Kaori Kitaoka Mika Takeuchi Miki Kurata Tsutomu Kazumi Keisuke Fukuo Bin Wu Mari Honda Satomi Minato-Inokawa Ayaka Tsuboi-Kaji Asami Hashiguchi |
| author_facet | Kaori Kitaoka Mika Takeuchi Miki Kurata Tsutomu Kazumi Keisuke Fukuo Bin Wu Mari Honda Satomi Minato-Inokawa Ayaka Tsuboi-Kaji Asami Hashiguchi |
| author_sort | Kaori Kitaoka |
| collection | DOAJ |
| description | Introduction We tested whether normal-weight obesity might be associated with weight trajectories, body composition and metabolic traits.Research design and methods Body size trajectory since birth, body composition at age 20 years and metabolic traits were compared cross-sectionally among normal-weight Japanese women with low (<25.0%, n=67), normal (25.0–34.9%, n=160) and high (≥35.0 %, n=24) percentage body fat. Multivariate logistic regression analyses were used to identify most important determinants of normal-weight obesity (high percentage body fat).Results Fasting glucose averaged <84 mg/dL, homeostasis model assessment-insulin resistance <1.4 and triglyceride <70 mg/dL and did not differ among three groups. However, waist and trunk/leg fat ratio were higher, and weight-adjusted skeletal muscle mass was lower in normal-weight obesity. Serum and LDL cholesterol, apolipoprotein B (ApoB) and high-sensitivity C reactive protein were higher, and apolipoprotein A1 was lower in normal-weight obesity compared with the other two groups, whereas HDL cholesterol did not differ. Weight gain from birth to age 12 years was higher in normal-weight obesity. In multivariate logistic regression analyses, weight gain until 12 years (OR: 1.17,95% CI 1.02 to 1.34, p=0.02), ApoB (OR: 1.15, 95% CI 1.06 to 1.24, p<0.001) and weight-adjusted skeletal muscle mass (OR: 0.22, 95% CI 0.10 to 0.49, p<0.001) were associated with normal-weight obesity independently of trunk/leg fat ratio, high-sensitivity C reactive protein and apolipoprotein A1.Conclusions Normal-weight obesity may be associated with early childhood growth, lower skeletal muscle mass and higher serum ApoB in young Japanese women through mechanisms unrelated to abdominal adiposity, inflammation and insulin resistance. |
| first_indexed | 2024-03-13T01:28:51Z |
| format | Article |
| id | doaj.art-21d527284a38465ea53092427c469f22 |
| institution | Directory Open Access Journal |
| issn | 2052-4897 |
| language | English |
| last_indexed | 2024-03-13T01:28:51Z |
| publishDate | 2022-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj.art-21d527284a38465ea53092427c469f222023-07-04T10:00:06ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972022-11-0110610.1136/bmjdrc-2022-003045Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fatKaori Kitaoka0Mika Takeuchi1Miki Kurata2Tsutomu Kazumi3Keisuke Fukuo4Bin Wu5Mari Honda6Satomi Minato-Inokawa7Ayaka Tsuboi-Kaji8Asami Hashiguchi9Department of Public Health, Shiga University of Medical Science, Otsu, JapanResearch Institute for Nutrition Sciences, Mukogawa Joshi Daigaku, Nishinomiya, JapanDepartment of Food Sciences and Nutrition, Mukogawa Joshi Daigaku, Nishinomiya, JapanEiyo kagakukenkyujo, Mukogawa Joshi Daigaku, Nishinomiya, JapanDepartment of Food Sciences and Nutrition, Mukogawa Joshi Daigaku, Nishinomiya, JapanFirst Affiliated Hospital of Kunming Medical University, Kunming, ChinaOpen Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Joshi Daigaku, Nishinomiya, Hyogo, JapanResearch Institute for Nutrition Sciences, Mukogawa Joshi Daigaku, Nishinomiya, JapanMukogawa Joshi Daigaku Eiyo Kagaku Kenkyujo, Nishinomiya, Hyogo, JapanDepartment of Food Sciences and Nutrition, Mukogawa Joshi Daigaku, Nishinomiya, JapanIntroduction We tested whether normal-weight obesity might be associated with weight trajectories, body composition and metabolic traits.Research design and methods Body size trajectory since birth, body composition at age 20 years and metabolic traits were compared cross-sectionally among normal-weight Japanese women with low (<25.0%, n=67), normal (25.0–34.9%, n=160) and high (≥35.0 %, n=24) percentage body fat. Multivariate logistic regression analyses were used to identify most important determinants of normal-weight obesity (high percentage body fat).Results Fasting glucose averaged <84 mg/dL, homeostasis model assessment-insulin resistance <1.4 and triglyceride <70 mg/dL and did not differ among three groups. However, waist and trunk/leg fat ratio were higher, and weight-adjusted skeletal muscle mass was lower in normal-weight obesity. Serum and LDL cholesterol, apolipoprotein B (ApoB) and high-sensitivity C reactive protein were higher, and apolipoprotein A1 was lower in normal-weight obesity compared with the other two groups, whereas HDL cholesterol did not differ. Weight gain from birth to age 12 years was higher in normal-weight obesity. In multivariate logistic regression analyses, weight gain until 12 years (OR: 1.17,95% CI 1.02 to 1.34, p=0.02), ApoB (OR: 1.15, 95% CI 1.06 to 1.24, p<0.001) and weight-adjusted skeletal muscle mass (OR: 0.22, 95% CI 0.10 to 0.49, p<0.001) were associated with normal-weight obesity independently of trunk/leg fat ratio, high-sensitivity C reactive protein and apolipoprotein A1.Conclusions Normal-weight obesity may be associated with early childhood growth, lower skeletal muscle mass and higher serum ApoB in young Japanese women through mechanisms unrelated to abdominal adiposity, inflammation and insulin resistance.https://drc.bmj.com/content/10/6/e003045.full |
| spellingShingle | Kaori Kitaoka Mika Takeuchi Miki Kurata Tsutomu Kazumi Keisuke Fukuo Bin Wu Mari Honda Satomi Minato-Inokawa Ayaka Tsuboi-Kaji Asami Hashiguchi Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat BMJ Open Diabetes Research & Care |
| title | Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat |
| title_full | Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat |
| title_fullStr | Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat |
| title_full_unstemmed | Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat |
| title_short | Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat |
| title_sort | weight trajectories since birth current body composition and metabolic traits in young normal weight japanese women with high percentage body fat |
| url | https://drc.bmj.com/content/10/6/e003045.full |
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