Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis

Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in the pathogenesis of this disease has not been...

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Bibliographic Details
Main Authors: Jianqiu Xiao, Kai Sun, Chun Wang, Yousef Abu-Amer, Gabriel Mbalaviele
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Journal of Translational Autoimmunity
Subjects:
GSDMD
GSDME
DSS
Colitis
Inflammation
Disulfiram
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909022000235

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