Hemophilia A Resulting in Severe Hyperesthesia Due to Extraparenchymal Spinal Cord Hemorrhage in a Young Golden Retriever Puppy
A ten-week-old male Golden retriever puppy was presented with severe hyperesthesia, mild neurological deficits and episcleral bleeding. Clotting times showed a normal prothrombin time (PT) and prolonged activated partial thromboplastin time (aPPT). Computed tomography (CT) of the vertebral column sh...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/11/638 |
| _version_ | 1797463803531624448 |
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| author | Charlotte Lubbers Martijn Beukers Niklas Bergknut Geert Paes |
| author_facet | Charlotte Lubbers Martijn Beukers Niklas Bergknut Geert Paes |
| author_sort | Charlotte Lubbers |
| collection | DOAJ |
| description | A ten-week-old male Golden retriever puppy was presented with severe hyperesthesia, mild neurological deficits and episcleral bleeding. Clotting times showed a normal prothrombin time (PT) and prolonged activated partial thromboplastin time (aPPT). Computed tomography (CT) of the vertebral column showed intradural, extraparenchymal hyperattenuating changes on precontrast CT images and epidural mass lesions, suggestive of hematorrhachis. Hemophilia A was confirmed by a low-factor VIII activity (FVIII:C). Although the dog improved clinically with intravenous analgesia and cage rest, it was euthanized by the owners’ choice because of the risk of developing future episodes of spontaneous hemorrhage. In young male puppies with severe hyperesthesia and mild neurological deficits, hemophilia A should be considered as a possible differential diagnosis. |
| first_indexed | 2024-03-09T17:55:55Z |
| format | Article |
| id | doaj.art-21d6db99f1034a91a887cfa8d875c40a |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T17:55:55Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-21d6db99f1034a91a887cfa8d875c40a2023-11-24T10:17:49ZengMDPI AGVeterinary Sciences2306-73812022-11-0191163810.3390/vetsci9110638Hemophilia A Resulting in Severe Hyperesthesia Due to Extraparenchymal Spinal Cord Hemorrhage in a Young Golden Retriever PuppyCharlotte Lubbers0Martijn Beukers1Niklas Bergknut2Geert Paes3Pride Veterinary Centre, Riverside Rd, Derby DE24 8HX, UKIVC Evidensia Dierenziekenhuis Hart van Brabant, Eerste Zeine 112, 5144 AM Waalwijk, The NetherlandsIVC Evidensia Dierenziekenhuis Hart van Brabant, Eerste Zeine 112, 5144 AM Waalwijk, The NetherlandsIVC Evidensia Dierenziekenhuis Hart van Brabant, Eerste Zeine 112, 5144 AM Waalwijk, The NetherlandsA ten-week-old male Golden retriever puppy was presented with severe hyperesthesia, mild neurological deficits and episcleral bleeding. Clotting times showed a normal prothrombin time (PT) and prolonged activated partial thromboplastin time (aPPT). Computed tomography (CT) of the vertebral column showed intradural, extraparenchymal hyperattenuating changes on precontrast CT images and epidural mass lesions, suggestive of hematorrhachis. Hemophilia A was confirmed by a low-factor VIII activity (FVIII:C). Although the dog improved clinically with intravenous analgesia and cage rest, it was euthanized by the owners’ choice because of the risk of developing future episodes of spontaneous hemorrhage. In young male puppies with severe hyperesthesia and mild neurological deficits, hemophilia A should be considered as a possible differential diagnosis.https://www.mdpi.com/2306-7381/9/11/638hemophilia Ahematorrhachishyperesthesia |
| spellingShingle | Charlotte Lubbers Martijn Beukers Niklas Bergknut Geert Paes Hemophilia A Resulting in Severe Hyperesthesia Due to Extraparenchymal Spinal Cord Hemorrhage in a Young Golden Retriever Puppy Veterinary Sciences hemophilia A hematorrhachis hyperesthesia |
| title | Hemophilia A Resulting in Severe Hyperesthesia Due to Extraparenchymal Spinal Cord Hemorrhage in a Young Golden Retriever Puppy |
| title_full | Hemophilia A Resulting in Severe Hyperesthesia Due to Extraparenchymal Spinal Cord Hemorrhage in a Young Golden Retriever Puppy |
| title_fullStr | Hemophilia A Resulting in Severe Hyperesthesia Due to Extraparenchymal Spinal Cord Hemorrhage in a Young Golden Retriever Puppy |
| title_full_unstemmed | Hemophilia A Resulting in Severe Hyperesthesia Due to Extraparenchymal Spinal Cord Hemorrhage in a Young Golden Retriever Puppy |
| title_short | Hemophilia A Resulting in Severe Hyperesthesia Due to Extraparenchymal Spinal Cord Hemorrhage in a Young Golden Retriever Puppy |
| title_sort | hemophilia a resulting in severe hyperesthesia due to extraparenchymal spinal cord hemorrhage in a young golden retriever puppy |
| topic | hemophilia A hematorrhachis hyperesthesia |
| url | https://www.mdpi.com/2306-7381/9/11/638 |
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