Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer
Ling Lu,1,* Qiaoyan Liang,2,* Xinyi Zhang,3 Yumeng Xu,3 Dehua Meng,4 Zhaofeng Liang3 1Child Healthcare Department, the Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2Health Care Department, People’s Liberation Army Navy No. 971 Hospital, Qin...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-07-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/autophagy-related-noncoding-rnas-emerging-regulatory-factors-of-gastri-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1811218751423512576 |
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| author | Lu L Liang Q Zhang X Xu Y Meng D Liang Z |
| author_facet | Lu L Liang Q Zhang X Xu Y Meng D Liang Z |
| author_sort | Lu L |
| collection | DOAJ |
| description | Ling Lu,1,* Qiaoyan Liang,2,* Xinyi Zhang,3 Yumeng Xu,3 Dehua Meng,4 Zhaofeng Liang3 1Child Healthcare Department, the Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2Health Care Department, People’s Liberation Army Navy No. 971 Hospital, Qingdao, People’s Republic of China; 3School of Medicine, Jiangsu University, Zhenjiang, People’s Republic of China; 4Department of Allergy, Dongtai People’s Hospital, Yancheng, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaofeng Liang, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People’s Republic of China, Email liangzhaofeng@ujs.edu.cn Dehua Meng, Department of Allergy, Dongtai People’s Hospital, 02 Fukang West Road, Yancheng, Jiangsu, 224200, People’s Republic of China, Email 2798184241@qq.comAbstract: Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical role in the occurrence and development of a variety of diseases including GC. In recent years, increasing attention has been given to research on autophagy-related ncRNAs, such as miRNA, lncRNA, and circRNA in GC. Herein, we briefly summarize the roles, functions, and the research progress of autophagy and autophagy-related ncRNAs in GC with a focus on the potential application in GC tumorigenesis, development, prognosis, and drug resistance. We also discussed prospects of clinical application, future research direction, and challenges in future research of autophagy-related ncRNAs.Keywords: gastric cancer, autophagy, noncoding RNA, function |
| first_indexed | 2024-04-12T07:14:40Z |
| format | Article |
| id | doaj.art-21d704503b204355be7a7ffd90247a50 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-12T07:14:40Z |
| publishDate | 2022-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-21d704503b204355be7a7ffd90247a502022-12-22T03:42:30ZengDove Medical PressCancer Management and Research1179-13222022-07-01Volume 142215222476662Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric CancerLu LLiang QZhang XXu YMeng DLiang ZLing Lu,1,* Qiaoyan Liang,2,* Xinyi Zhang,3 Yumeng Xu,3 Dehua Meng,4 Zhaofeng Liang3 1Child Healthcare Department, the Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2Health Care Department, People’s Liberation Army Navy No. 971 Hospital, Qingdao, People’s Republic of China; 3School of Medicine, Jiangsu University, Zhenjiang, People’s Republic of China; 4Department of Allergy, Dongtai People’s Hospital, Yancheng, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaofeng Liang, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, People’s Republic of China, Email liangzhaofeng@ujs.edu.cn Dehua Meng, Department of Allergy, Dongtai People’s Hospital, 02 Fukang West Road, Yancheng, Jiangsu, 224200, People’s Republic of China, Email 2798184241@qq.comAbstract: Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical role in the occurrence and development of a variety of diseases including GC. In recent years, increasing attention has been given to research on autophagy-related ncRNAs, such as miRNA, lncRNA, and circRNA in GC. Herein, we briefly summarize the roles, functions, and the research progress of autophagy and autophagy-related ncRNAs in GC with a focus on the potential application in GC tumorigenesis, development, prognosis, and drug resistance. We also discussed prospects of clinical application, future research direction, and challenges in future research of autophagy-related ncRNAs.Keywords: gastric cancer, autophagy, noncoding RNA, functionhttps://www.dovepress.com/autophagy-related-noncoding-rnas-emerging-regulatory-factors-of-gastri-peer-reviewed-fulltext-article-CMARgastric cancerautophagynoncoding rnafunction |
| spellingShingle | Lu L Liang Q Zhang X Xu Y Meng D Liang Z Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer Cancer Management and Research gastric cancer autophagy noncoding rna function |
| title | Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer |
| title_full | Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer |
| title_fullStr | Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer |
| title_full_unstemmed | Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer |
| title_short | Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer |
| title_sort | autophagy related noncoding rnas emerging regulatory factors of gastric cancer |
| topic | gastric cancer autophagy noncoding rna function |
| url | https://www.dovepress.com/autophagy-related-noncoding-rnas-emerging-regulatory-factors-of-gastri-peer-reviewed-fulltext-article-CMAR |
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