Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections
Background Soil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Trisakti University
2016-12-01
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| Series: | Universa Medicina |
| Subjects: | |
| Online Access: | https://univmed.org/ejurnal/index.php/medicina/article/view/254 |
| _version_ | 1818963054042284032 |
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| author | Ria Buana Jane Florida Kalumpiu Yenny Djuardi Taniawati Supali |
| author_facet | Ria Buana Jane Florida Kalumpiu Yenny Djuardi Taniawati Supali |
| author_sort | Ria Buana |
| collection | DOAJ |
| description | Background
Soil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta.
Methods
A pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data.
Results
The STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment.
Conclusions
Albendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world. |
| first_indexed | 2024-12-20T12:39:07Z |
| format | Article |
| id | doaj.art-21d755884f124976822104a38b65682f |
| institution | Directory Open Access Journal |
| issn | 1907-3062 2407-2230 |
| language | English |
| last_indexed | 2024-12-20T12:39:07Z |
| publishDate | 2016-12-01 |
| publisher | Faculty of Medicine Trisakti University |
| record_format | Article |
| series | Universa Medicina |
| spelling | doaj.art-21d755884f124976822104a38b65682f2022-12-21T19:40:32ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622407-22302016-12-0135320621210.18051/UnivMed.2016.v35.206-212279Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infectionsRia Buana0Jane Florida Kalumpiu1Yenny Djuardi2Taniawati Supali3Department of Parasitology, Faculty of Medicine, Tarumanagara UniversityDepartment of Parasitology, Faculty of Medicine, Trisakti University, JakartaDepartment of Parasitology, Faculty of Medicine, University of Indonesia, JakartaDepartment of Parasitology, Faculty of Medicine, University of Indonesia, JakartaBackground Soil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. Methods A pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. Results The STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. Conclusions Albendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.https://univmed.org/ejurnal/index.php/medicina/article/view/254serum zincalbendazolesthchildren |
| spellingShingle | Ria Buana Jane Florida Kalumpiu Yenny Djuardi Taniawati Supali Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections Universa Medicina serum zinc albendazole sth children |
| title | Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections |
| title_full | Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections |
| title_fullStr | Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections |
| title_full_unstemmed | Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections |
| title_short | Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections |
| title_sort | albendazole therapy reduces serum zinc in elementary school children with ascaris lumbricoides infections |
| topic | serum zinc albendazole sth children |
| url | https://univmed.org/ejurnal/index.php/medicina/article/view/254 |
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