The significance of homeodomain transcription factor 2 in colon cancer cells
Abstract Background Colon cancer is a serious malignant tumor. It has been reported that paired-like homeodomain transcription factor 2 (PITX2) can promote the progression of several types of cancer via regulating the Wnt/β-catenin pathway. It has also been demonstrated that high levels of long non-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-021-00912-5 |
| _version_ | 1819089801608953856 |
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| author | Yang He Peng Gong Sitong Wang Qing Xu Jianhua Chen |
| author_facet | Yang He Peng Gong Sitong Wang Qing Xu Jianhua Chen |
| author_sort | Yang He |
| collection | DOAJ |
| description | Abstract Background Colon cancer is a serious malignant tumor. It has been reported that paired-like homeodomain transcription factor 2 (PITX2) can promote the progression of several types of cancer via regulating the Wnt/β-catenin pathway. It has also been demonstrated that high levels of long non-coding RNA (lncRNA) gastric carcinoma high expressed transcript 1 (GHET1) can also promote the development of cervical cancer via activating the Wnt/β-catenin pathway. However, whether PITX2 can affect the development of colon cancer via regulating the expression of lncRNA GHET1 remains unclear. Results The results demonstrated that PITX2 knockdown attenuated the proliferation, migration and invasion abilities of colon cancer cells. Additionally, PITX2 promoted the expression of lncRNA GHET1 via binding to its promoter. Overexpression of lncRNA GHET1 induced the expression of Wnt/β-catenin signaling-related proteins, cyclin D1, c-Myc and MMP-7. Furthermore, lncRNA GHET1 overexpression abrogated the PITX2 silencing-mediated decreased proliferation, migration and invasion abilities of colon cancer cells. Conclusion The findings of the present study suggested that PITX2 could enhance the proliferation, migration and invasion abilities of colon cancer cells via upregulating lncRNA GHET1 and activating the Wnt/β-catenin pathway. |
| first_indexed | 2024-12-21T22:13:43Z |
| format | Article |
| id | doaj.art-21d8e48240624fa99f0be9b004df24ac |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-12-21T22:13:43Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-21d8e48240624fa99f0be9b004df24ac2022-12-21T18:48:31ZengBMCBioMedical Engineering OnLine1475-925X2021-08-0120111210.1186/s12938-021-00912-5The significance of homeodomain transcription factor 2 in colon cancer cellsYang He0Peng Gong1Sitong Wang2Qing Xu3Jianhua Chen4Department of Oncology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Oncology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Oncology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Oncology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Oncology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineAbstract Background Colon cancer is a serious malignant tumor. It has been reported that paired-like homeodomain transcription factor 2 (PITX2) can promote the progression of several types of cancer via regulating the Wnt/β-catenin pathway. It has also been demonstrated that high levels of long non-coding RNA (lncRNA) gastric carcinoma high expressed transcript 1 (GHET1) can also promote the development of cervical cancer via activating the Wnt/β-catenin pathway. However, whether PITX2 can affect the development of colon cancer via regulating the expression of lncRNA GHET1 remains unclear. Results The results demonstrated that PITX2 knockdown attenuated the proliferation, migration and invasion abilities of colon cancer cells. Additionally, PITX2 promoted the expression of lncRNA GHET1 via binding to its promoter. Overexpression of lncRNA GHET1 induced the expression of Wnt/β-catenin signaling-related proteins, cyclin D1, c-Myc and MMP-7. Furthermore, lncRNA GHET1 overexpression abrogated the PITX2 silencing-mediated decreased proliferation, migration and invasion abilities of colon cancer cells. Conclusion The findings of the present study suggested that PITX2 could enhance the proliferation, migration and invasion abilities of colon cancer cells via upregulating lncRNA GHET1 and activating the Wnt/β-catenin pathway.https://doi.org/10.1186/s12938-021-00912-5Colon cancerPaired-like homeodomain transcription factor 2Long non-coding RNA gastric carcinoma high expressed transcript 1Wnt/β-catenin pathwayProliferationInvasion |
| spellingShingle | Yang He Peng Gong Sitong Wang Qing Xu Jianhua Chen The significance of homeodomain transcription factor 2 in colon cancer cells BioMedical Engineering OnLine Colon cancer Paired-like homeodomain transcription factor 2 Long non-coding RNA gastric carcinoma high expressed transcript 1 Wnt/β-catenin pathway Proliferation Invasion |
| title | The significance of homeodomain transcription factor 2 in colon cancer cells |
| title_full | The significance of homeodomain transcription factor 2 in colon cancer cells |
| title_fullStr | The significance of homeodomain transcription factor 2 in colon cancer cells |
| title_full_unstemmed | The significance of homeodomain transcription factor 2 in colon cancer cells |
| title_short | The significance of homeodomain transcription factor 2 in colon cancer cells |
| title_sort | significance of homeodomain transcription factor 2 in colon cancer cells |
| topic | Colon cancer Paired-like homeodomain transcription factor 2 Long non-coding RNA gastric carcinoma high expressed transcript 1 Wnt/β-catenin pathway Proliferation Invasion |
| url | https://doi.org/10.1186/s12938-021-00912-5 |
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