Crosstalk Between microRNAs and the Pathological Features of Secondary Lymphedema
Secondary lymphedema is characterized by lymphatic fluid retention and subsequent tissue swelling in one or both limbs that can lead to decreased quality of life. It often arises after loss, obstruction, or blockage of lymphatic vessels due to multifactorial modalities, such as lymphatic insults aft...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.732415/full |
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| author | Khairunnisa’ Md Yusof Khairunnisa’ Md Yusof Khairunnisa’ Md Yusof Kira Groen Kira Groen Rozita Rosli Rozita Rosli Kelly A. Avery-Kiejda Kelly A. Avery-Kiejda |
| author_facet | Khairunnisa’ Md Yusof Khairunnisa’ Md Yusof Khairunnisa’ Md Yusof Kira Groen Kira Groen Rozita Rosli Rozita Rosli Kelly A. Avery-Kiejda Kelly A. Avery-Kiejda |
| author_sort | Khairunnisa’ Md Yusof |
| collection | DOAJ |
| description | Secondary lymphedema is characterized by lymphatic fluid retention and subsequent tissue swelling in one or both limbs that can lead to decreased quality of life. It often arises after loss, obstruction, or blockage of lymphatic vessels due to multifactorial modalities, such as lymphatic insults after surgery, immune system dysfunction, deposition of fat that compresses the lymphatic capillaries, fibrosis, and inflammation. Although secondary lymphedema is often associated with breast cancer, the condition can occur in patients with any type of cancer that requires lymphadenectomy such as gynecological, genitourinary, or head and neck cancers. MicroRNAs demonstrate pivotal roles in regulating gene expression in biological processes such as lymphangiogenesis, angiogenesis, modulation of the immune system, and oxidative stress. MicroRNA profiling has led to the discovery of the molecular mechanisms involved in the pathophysiology of auto-immune, inflammation-related, and metabolic diseases. Although the role of microRNAs in regulating secondary lymphedema is yet to be elucidated, the crosstalk between microRNAs and molecular factors involved in the pathological features of lymphedema, such as skin fibrosis, inflammation, immune dysregulation, and aberrant lipid metabolism have been demonstrated in several studies. MicroRNAs have the potential to serve as biomarkers for diseases and elucidation of their roles in lymphedema can provide a better understanding or new insights of the mechanisms underlying this debilitating condition. |
| first_indexed | 2024-12-19T17:56:20Z |
| format | Article |
| id | doaj.art-21da2aa09f314711a6349dcb910cde60 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T17:56:20Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-21da2aa09f314711a6349dcb910cde602022-12-21T20:11:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-10-01910.3389/fcell.2021.732415732415Crosstalk Between microRNAs and the Pathological Features of Secondary LymphedemaKhairunnisa’ Md Yusof0Khairunnisa’ Md Yusof1Khairunnisa’ Md Yusof2Kira Groen3Kira Groen4Rozita Rosli5Rozita Rosli6Kelly A. Avery-Kiejda7Kelly A. Avery-Kiejda8Hunter Medical Research Institute, New Lambton Heights, NSW, AustraliaSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, NSW, AustraliaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaHunter Medical Research Institute, New Lambton Heights, NSW, AustraliaSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, NSW, AustraliaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaUPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, MalaysiaHunter Medical Research Institute, New Lambton Heights, NSW, AustraliaSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, NSW, AustraliaSecondary lymphedema is characterized by lymphatic fluid retention and subsequent tissue swelling in one or both limbs that can lead to decreased quality of life. It often arises after loss, obstruction, or blockage of lymphatic vessels due to multifactorial modalities, such as lymphatic insults after surgery, immune system dysfunction, deposition of fat that compresses the lymphatic capillaries, fibrosis, and inflammation. Although secondary lymphedema is often associated with breast cancer, the condition can occur in patients with any type of cancer that requires lymphadenectomy such as gynecological, genitourinary, or head and neck cancers. MicroRNAs demonstrate pivotal roles in regulating gene expression in biological processes such as lymphangiogenesis, angiogenesis, modulation of the immune system, and oxidative stress. MicroRNA profiling has led to the discovery of the molecular mechanisms involved in the pathophysiology of auto-immune, inflammation-related, and metabolic diseases. Although the role of microRNAs in regulating secondary lymphedema is yet to be elucidated, the crosstalk between microRNAs and molecular factors involved in the pathological features of lymphedema, such as skin fibrosis, inflammation, immune dysregulation, and aberrant lipid metabolism have been demonstrated in several studies. MicroRNAs have the potential to serve as biomarkers for diseases and elucidation of their roles in lymphedema can provide a better understanding or new insights of the mechanisms underlying this debilitating condition.https://www.frontiersin.org/articles/10.3389/fcell.2021.732415/fullmicroRNAlymphaticslymphangiogenesisfibrosisinflammationlymphedema |
| spellingShingle | Khairunnisa’ Md Yusof Khairunnisa’ Md Yusof Khairunnisa’ Md Yusof Kira Groen Kira Groen Rozita Rosli Rozita Rosli Kelly A. Avery-Kiejda Kelly A. Avery-Kiejda Crosstalk Between microRNAs and the Pathological Features of Secondary Lymphedema Frontiers in Cell and Developmental Biology microRNA lymphatics lymphangiogenesis fibrosis inflammation lymphedema |
| title | Crosstalk Between microRNAs and the Pathological Features of Secondary Lymphedema |
| title_full | Crosstalk Between microRNAs and the Pathological Features of Secondary Lymphedema |
| title_fullStr | Crosstalk Between microRNAs and the Pathological Features of Secondary Lymphedema |
| title_full_unstemmed | Crosstalk Between microRNAs and the Pathological Features of Secondary Lymphedema |
| title_short | Crosstalk Between microRNAs and the Pathological Features of Secondary Lymphedema |
| title_sort | crosstalk between micrornas and the pathological features of secondary lymphedema |
| topic | microRNA lymphatics lymphangiogenesis fibrosis inflammation lymphedema |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.732415/full |
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