Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia

During placental development, cytotrophoblast progenitor cells differentiate into the syncytiotrophoblast and invasive extravillous trophoblasts (EVTs). Some EVTs further differentiate into endovascular trophoblasts (enEVTs) which exhibit endothelial-like properties. Abnormal placental development,...

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Bibliographic Details
Main Authors: Jelena Brkić, Caroline Dunk, Yanan Shan, Jacob Anderson O'Brien, Phetcharawan Lye, Sheza Qayyum, Peifeng Yang, Stephen G. Matthews, Stephen J. Lye, Chun Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Endocrinology
Subjects:
Smad2
Smad3
preeclampsia
placenta
endovascular trophoblasts
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00436/full

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