EGFR and p38<sup>MAPK</sup> Contribute to the Apoptotic Effect of the Recombinant Lectin from Tepary Bean (<i>Phaseolus acutifolius</i>) in Colon Cancer Cells

EGFR and p38<sup>MAPK</sup> Contribute to the Apoptotic Effect of the Recombinant Lectin from Tepary Bean (<i>Phaseolus acutifolius</i>) in Colon Cancer Cells

Previous works showed that a Tepary bean lectin fraction (TBLF) induced apoptosis on colon cancer cells and inhibited early colonic tumorigenesis. One Tepary bean (TB) lectin was expressed in <i>Pichia pastoris</i> (rTBL-1), exhibiting similarities to one native lectin, where its molecul...

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Bibliographic Details
Main Authors: José Luis Dena-Beltrán, Porfirio Nava-Domínguez, Dulce Palmerín-Carreño, Dania Martínez-Alarcón, Ulisses Moreno-Celis, Magali Valle-Pacheco, José Luis Castro-Guillén, Alejandro Blanco-Labra, Teresa García-Gasca
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
apoptosis
colon cancer
cytotoxic
EGFR
<i>Phaseolus acutifolius</i>
p38
Online Access:https://www.mdpi.com/1424-8247/16/2/290

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