Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines
Summary: The induction and maintenance of T cell memory is critical to the success of vaccines. A recently described subset of memory CD8+ T cells defined by intermediate expression of the chemokine receptor CX3CR1 was shown to have self-renewal, proliferative, and tissue-surveillance properties rel...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-04-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718304352 |
| _version_ | 1811289598856265728 |
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| author | Claire Louse Gordon Lian Ni Lee Leo Swadling Claire Hutchings Madeleine Zinser Andrew John Highton Stefania Capone Antonella Folgori Eleanor Barnes Paul Klenerman |
| author_facet | Claire Louse Gordon Lian Ni Lee Leo Swadling Claire Hutchings Madeleine Zinser Andrew John Highton Stefania Capone Antonella Folgori Eleanor Barnes Paul Klenerman |
| author_sort | Claire Louse Gordon |
| collection | DOAJ |
| description | Summary: The induction and maintenance of T cell memory is critical to the success of vaccines. A recently described subset of memory CD8+ T cells defined by intermediate expression of the chemokine receptor CX3CR1 was shown to have self-renewal, proliferative, and tissue-surveillance properties relevant to vaccine-induced memory. We tracked these cells when memory is sustained at high levels: memory inflation induced by cytomegalovirus (CMV) and adenovirus-vectored vaccines. In mice, both CMV and vaccine-induced inflationary T cells showed sustained high levels of CX3R1int cells exhibiting an effector-memory phenotype, characteristic of inflationary pools, in early memory. In humans, CX3CR1int CD8+ T cells were strongly induced following adenovirus-vectored vaccination for hepatitis C virus (HCV) (ChAd3-NSmut) and during natural CMV infection and were associated with a memory phenotype similar to that in mice. These data indicate that CX3CR1int cells form an important component of the memory pool in response to persistent viruses and vaccines in both mice and humans. : Gordon et al. demonstrate that CX3CR1int peripheral memory T cells are a substantial component of memory inflation induced by persistent CMVs and adenoviral vaccination. They are characterized by sustained proliferation and an effector-memory phenotype linked to these expanded CD8+ T cell memory responses. Core phenotypic features are shared by humans and mice. Keywords: cytomegalovirus, T cells, memory, adenovirus, vaccination, CX3CR1, memory inflation, mouse, human |
| first_indexed | 2024-04-13T03:58:27Z |
| format | Article |
| id | doaj.art-21dd4267120b448e8614fa543e1f01fe |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-13T03:58:27Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-21dd4267120b448e8614fa543e1f01fe2022-12-22T03:03:33ZengElsevierCell Reports2211-12472018-04-01233768782Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and VaccinesClaire Louse Gordon0Lian Ni Lee1Leo Swadling2Claire Hutchings3Madeleine Zinser4Andrew John Highton5Stefania Capone6Antonella Folgori7Eleanor Barnes8Paul Klenerman9Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX2 3SY, UKPeter Medawar Building for Pathogen Research, University of Oxford, Oxford OX2 3SY, UKPeter Medawar Building for Pathogen Research, University of Oxford, Oxford OX2 3SY, UKPeter Medawar Building for Pathogen Research, University of Oxford, Oxford OX2 3SY, UKPeter Medawar Building for Pathogen Research, University of Oxford, Oxford OX2 3SY, UKPeter Medawar Building for Pathogen Research, University of Oxford, Oxford OX2 3SY, UKReithera SRL (formerly Okairos SRL), Viale Città d’Europa 679, 00144 Rome, ItalyReithera SRL (formerly Okairos SRL), Viale Città d’Europa 679, 00144 Rome, ItalyPeter Medawar Building for Pathogen Research, University of Oxford, Oxford OX2 3SY, UKPeter Medawar Building for Pathogen Research, University of Oxford, Oxford OX2 3SY, UK; Corresponding authorSummary: The induction and maintenance of T cell memory is critical to the success of vaccines. A recently described subset of memory CD8+ T cells defined by intermediate expression of the chemokine receptor CX3CR1 was shown to have self-renewal, proliferative, and tissue-surveillance properties relevant to vaccine-induced memory. We tracked these cells when memory is sustained at high levels: memory inflation induced by cytomegalovirus (CMV) and adenovirus-vectored vaccines. In mice, both CMV and vaccine-induced inflationary T cells showed sustained high levels of CX3R1int cells exhibiting an effector-memory phenotype, characteristic of inflationary pools, in early memory. In humans, CX3CR1int CD8+ T cells were strongly induced following adenovirus-vectored vaccination for hepatitis C virus (HCV) (ChAd3-NSmut) and during natural CMV infection and were associated with a memory phenotype similar to that in mice. These data indicate that CX3CR1int cells form an important component of the memory pool in response to persistent viruses and vaccines in both mice and humans. : Gordon et al. demonstrate that CX3CR1int peripheral memory T cells are a substantial component of memory inflation induced by persistent CMVs and adenoviral vaccination. They are characterized by sustained proliferation and an effector-memory phenotype linked to these expanded CD8+ T cell memory responses. Core phenotypic features are shared by humans and mice. Keywords: cytomegalovirus, T cells, memory, adenovirus, vaccination, CX3CR1, memory inflation, mouse, humanhttp://www.sciencedirect.com/science/article/pii/S2211124718304352 |
| spellingShingle | Claire Louse Gordon Lian Ni Lee Leo Swadling Claire Hutchings Madeleine Zinser Andrew John Highton Stefania Capone Antonella Folgori Eleanor Barnes Paul Klenerman Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines Cell Reports |
| title | Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines |
| title_full | Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines |
| title_fullStr | Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines |
| title_full_unstemmed | Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines |
| title_short | Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines |
| title_sort | induction and maintenance of cx3cr1 intermediate peripheral memory cd8 t cells by persistent viruses and vaccines |
| url | http://www.sciencedirect.com/science/article/pii/S2211124718304352 |
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