Mesenchymal stem cells for treating autoimmune dacryoadenitis
Abstract Autoimmune dacryoadenitis, such as Sjögren syndrome, comprises multifactorial and complex diseases. Inflammation of the lacrimal gland plays a key role in the pathogenesis of diseases. Unfortunately, current treatment strategies, including artificial tears, anti-inflammatory drugs, punctual...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-017-0593-3 |
| _version_ | 1819043218412535808 |
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| author | Xiaoxiao Lu Xilian Wang Hong Nian Dan Yang Ruihua Wei |
| author_facet | Xiaoxiao Lu Xilian Wang Hong Nian Dan Yang Ruihua Wei |
| author_sort | Xiaoxiao Lu |
| collection | DOAJ |
| description | Abstract Autoimmune dacryoadenitis, such as Sjögren syndrome, comprises multifactorial and complex diseases. Inflammation of the lacrimal gland plays a key role in the pathogenesis of diseases. Unfortunately, current treatment strategies, including artificial tears, anti-inflammatory drugs, punctual occlusion, and immunosuppressive drugs, are only palliative, and long-term administration of these strategies is associated with adverse effects that limit their utility. Hence, an effective and safe treatment for autoimmune dacryoadenitis is urgently needed. Mesenchymal stem cells (MSCs) have emerged as a promising tool for treating autoimmune dacryoadenitis, owing to their immunosuppressive properties, tissue repair functions, and powerful differentiation capabilities. A large number of studies have focused on the effect of MSCs on autoimmune diseases, such as autoimmune uveitis, inflammatory bowel disease, and collagen-induced arthritis, but few studies have, to date, unequivocally established the efficacy of MSCs for treating autoimmune dacryoadenitis. In this review, we discuss recent advances in MSC treatment for autoimmune dacryoadenitis. |
| first_indexed | 2024-12-21T09:53:17Z |
| format | Article |
| id | doaj.art-21ddc9a2202940f4b1deeec6dbfc8ee4 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-21T09:53:17Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-21ddc9a2202940f4b1deeec6dbfc8ee42022-12-21T19:08:07ZengBMCStem Cell Research & Therapy1757-65122017-06-01811610.1186/s13287-017-0593-3Mesenchymal stem cells for treating autoimmune dacryoadenitisXiaoxiao Lu0Xilian Wang1Hong Nian2Dan Yang3Ruihua Wei4Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute & Tianjin Medical University School of Optometry and OphthalmologyTianjin Beichen HospitalTianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute & Tianjin Medical University School of Optometry and OphthalmologyTianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute & Tianjin Medical University School of Optometry and OphthalmologyTianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute & Tianjin Medical University School of Optometry and OphthalmologyAbstract Autoimmune dacryoadenitis, such as Sjögren syndrome, comprises multifactorial and complex diseases. Inflammation of the lacrimal gland plays a key role in the pathogenesis of diseases. Unfortunately, current treatment strategies, including artificial tears, anti-inflammatory drugs, punctual occlusion, and immunosuppressive drugs, are only palliative, and long-term administration of these strategies is associated with adverse effects that limit their utility. Hence, an effective and safe treatment for autoimmune dacryoadenitis is urgently needed. Mesenchymal stem cells (MSCs) have emerged as a promising tool for treating autoimmune dacryoadenitis, owing to their immunosuppressive properties, tissue repair functions, and powerful differentiation capabilities. A large number of studies have focused on the effect of MSCs on autoimmune diseases, such as autoimmune uveitis, inflammatory bowel disease, and collagen-induced arthritis, but few studies have, to date, unequivocally established the efficacy of MSCs for treating autoimmune dacryoadenitis. In this review, we discuss recent advances in MSC treatment for autoimmune dacryoadenitis.http://link.springer.com/article/10.1186/s13287-017-0593-3Mesenchymal stem cellsAutoimmune dacryoadenitisImmunomodulation |
| spellingShingle | Xiaoxiao Lu Xilian Wang Hong Nian Dan Yang Ruihua Wei Mesenchymal stem cells for treating autoimmune dacryoadenitis Stem Cell Research & Therapy Mesenchymal stem cells Autoimmune dacryoadenitis Immunomodulation |
| title | Mesenchymal stem cells for treating autoimmune dacryoadenitis |
| title_full | Mesenchymal stem cells for treating autoimmune dacryoadenitis |
| title_fullStr | Mesenchymal stem cells for treating autoimmune dacryoadenitis |
| title_full_unstemmed | Mesenchymal stem cells for treating autoimmune dacryoadenitis |
| title_short | Mesenchymal stem cells for treating autoimmune dacryoadenitis |
| title_sort | mesenchymal stem cells for treating autoimmune dacryoadenitis |
| topic | Mesenchymal stem cells Autoimmune dacryoadenitis Immunomodulation |
| url | http://link.springer.com/article/10.1186/s13287-017-0593-3 |
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