Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis

Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis

Abstract Metformin, a well‐known antidiabetic drug, has been repurposed for cancer treatment; however, recently observed drug resistance and tumor metastasis have questioned its further application. Here, we found that long‐term metformin exposure led to metabolic adaptation of hepatocellular carcin...

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Bibliographic Details
Main Authors: Ping Jin, Jingwen Jiang, Li Zhou, Zhao Huang, Siyuan Qin, Hai‐Ning Chen, Liyuan Peng, Zhe Zhang, Bowen Li, Maochao Luo, Tingting Zhang, Hui Ming, Ning Ding, Lei Li, Na Xie, Wei Gao, Wei Zhang, Edouard C Nice, Yuquan Wei, Canhua Huang
Format: Article
Language:English
Published: Springer Nature 2022-12-01
Series:EMBO Molecular Medicine
Subjects:
hepatocellular carcinoma
metastasis
metformin adaptation
oxidative phosphorylation
TOMM34
Online Access:https://doi.org/10.15252/emmm.202216082

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