Investigating different duplication pattern of essential genes in mouse and human.
Gene duplication is one of the major driving forces shaping genome and organism evolution and thought to be itself regulated by some intrinsic properties of the gene. Comparing the essential genes among mouse and human, we observed that the essential genes avoid duplication in mouse while prefer to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0120784 |
| _version_ | 1818934521231310848 |
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| author | Debarun Acharya Dola Mukherjee Soumita Podder Tapash C Ghosh |
| author_facet | Debarun Acharya Dola Mukherjee Soumita Podder Tapash C Ghosh |
| author_sort | Debarun Acharya |
| collection | DOAJ |
| description | Gene duplication is one of the major driving forces shaping genome and organism evolution and thought to be itself regulated by some intrinsic properties of the gene. Comparing the essential genes among mouse and human, we observed that the essential genes avoid duplication in mouse while prefer to remain duplicated in humans. In this study, we wanted to explore the reasons behind such differences in gene essentiality by cross-species comparison of human and mouse. Moreover, we examined essential genes that are duplicated in humans are functionally more redundant than that in mouse. The proportion of paralog pseudogenization of essential genes is higher in mouse than that of humans. These duplicates of essential genes are under stringent dosage regulation in human than in mouse. We also observed slower evolutionary rate in the paralogs of human essential genes than the mouse counterpart. Together, these results clearly indicate that human essential genes are retained as duplicates to serve as backed up copies that may shield themselves from harmful mutations. |
| first_indexed | 2024-12-20T05:05:36Z |
| format | Article |
| id | doaj.art-21dea9e2bf4e4dbd8f6b2d8c80d58d1b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T05:05:36Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-21dea9e2bf4e4dbd8f6b2d8c80d58d1b2022-12-21T19:52:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e012078410.1371/journal.pone.0120784Investigating different duplication pattern of essential genes in mouse and human.Debarun AcharyaDola MukherjeeSoumita PodderTapash C GhoshGene duplication is one of the major driving forces shaping genome and organism evolution and thought to be itself regulated by some intrinsic properties of the gene. Comparing the essential genes among mouse and human, we observed that the essential genes avoid duplication in mouse while prefer to remain duplicated in humans. In this study, we wanted to explore the reasons behind such differences in gene essentiality by cross-species comparison of human and mouse. Moreover, we examined essential genes that are duplicated in humans are functionally more redundant than that in mouse. The proportion of paralog pseudogenization of essential genes is higher in mouse than that of humans. These duplicates of essential genes are under stringent dosage regulation in human than in mouse. We also observed slower evolutionary rate in the paralogs of human essential genes than the mouse counterpart. Together, these results clearly indicate that human essential genes are retained as duplicates to serve as backed up copies that may shield themselves from harmful mutations.https://doi.org/10.1371/journal.pone.0120784 |
| spellingShingle | Debarun Acharya Dola Mukherjee Soumita Podder Tapash C Ghosh Investigating different duplication pattern of essential genes in mouse and human. PLoS ONE |
| title | Investigating different duplication pattern of essential genes in mouse and human. |
| title_full | Investigating different duplication pattern of essential genes in mouse and human. |
| title_fullStr | Investigating different duplication pattern of essential genes in mouse and human. |
| title_full_unstemmed | Investigating different duplication pattern of essential genes in mouse and human. |
| title_short | Investigating different duplication pattern of essential genes in mouse and human. |
| title_sort | investigating different duplication pattern of essential genes in mouse and human |
| url | https://doi.org/10.1371/journal.pone.0120784 |
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