Ovarian cancer immunotherapy: opportunities, progresses and challenges
<p>Abstract</p> <p>Due to the low survival rates from invasive ovarian cancer, new effective treatment modalities are urgently needed. Compelling evidence indicates that the immune response against ovarian cancer may play an important role in controlling this disease. We herein sum...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-02-01
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| Series: | Journal of Hematology & Oncology |
| Online Access: | http://www.jhoonline.org/content/3/1/7 |
| _version_ | 1818473266239504384 |
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| author | Stevens Richard Swede Helen Runowicz Carolyn Nash John Liu Bei Li Zihai |
| author_facet | Stevens Richard Swede Helen Runowicz Carolyn Nash John Liu Bei Li Zihai |
| author_sort | Stevens Richard |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Due to the low survival rates from invasive ovarian cancer, new effective treatment modalities are urgently needed. Compelling evidence indicates that the immune response against ovarian cancer may play an important role in controlling this disease. We herein summarize multiple immune-based strategies that have been proposed and tested for potential therapeutic benefit against advanced stage ovarian cancer. We will examine the evidence for the premise that an effective therapeutic vaccine against ovarian cancer is useful not only for inducing remission of the disease but also for preventing disease relapse. We will also highlight the questions and challenges in the development of ovarian cancer vaccines, and critically discuss the limitations of some of the existing immunotherapeutic strategies. Finally, we will summarize our own experience on the use of patient-specific tumor-derived heat shock protein-peptide complex for the treatment of advanced ovarian cancer.</p> |
| first_indexed | 2024-04-14T04:21:39Z |
| format | Article |
| id | doaj.art-21df87402afa4c8587c1d98b8dd3aa51 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-04-14T04:21:39Z |
| publishDate | 2010-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-21df87402afa4c8587c1d98b8dd3aa512022-12-22T02:12:30ZengBMCJournal of Hematology & Oncology1756-87222010-02-0131710.1186/1756-8722-3-7Ovarian cancer immunotherapy: opportunities, progresses and challengesStevens RichardSwede HelenRunowicz CarolynNash JohnLiu BeiLi Zihai<p>Abstract</p> <p>Due to the low survival rates from invasive ovarian cancer, new effective treatment modalities are urgently needed. Compelling evidence indicates that the immune response against ovarian cancer may play an important role in controlling this disease. We herein summarize multiple immune-based strategies that have been proposed and tested for potential therapeutic benefit against advanced stage ovarian cancer. We will examine the evidence for the premise that an effective therapeutic vaccine against ovarian cancer is useful not only for inducing remission of the disease but also for preventing disease relapse. We will also highlight the questions and challenges in the development of ovarian cancer vaccines, and critically discuss the limitations of some of the existing immunotherapeutic strategies. Finally, we will summarize our own experience on the use of patient-specific tumor-derived heat shock protein-peptide complex for the treatment of advanced ovarian cancer.</p>http://www.jhoonline.org/content/3/1/7 |
| spellingShingle | Stevens Richard Swede Helen Runowicz Carolyn Nash John Liu Bei Li Zihai Ovarian cancer immunotherapy: opportunities, progresses and challenges Journal of Hematology & Oncology |
| title | Ovarian cancer immunotherapy: opportunities, progresses and challenges |
| title_full | Ovarian cancer immunotherapy: opportunities, progresses and challenges |
| title_fullStr | Ovarian cancer immunotherapy: opportunities, progresses and challenges |
| title_full_unstemmed | Ovarian cancer immunotherapy: opportunities, progresses and challenges |
| title_short | Ovarian cancer immunotherapy: opportunities, progresses and challenges |
| title_sort | ovarian cancer immunotherapy opportunities progresses and challenges |
| url | http://www.jhoonline.org/content/3/1/7 |
| work_keys_str_mv | AT stevensrichard ovariancancerimmunotherapyopportunitiesprogressesandchallenges AT swedehelen ovariancancerimmunotherapyopportunitiesprogressesandchallenges AT runowiczcarolyn ovariancancerimmunotherapyopportunitiesprogressesandchallenges AT nashjohn ovariancancerimmunotherapyopportunitiesprogressesandchallenges AT liubei ovariancancerimmunotherapyopportunitiesprogressesandchallenges AT lizihai ovariancancerimmunotherapyopportunitiesprogressesandchallenges |