TRENDS IN MORTALITY OF POTENTIAL PNEUMOCOCCAL PNEUMONIA IN COLOMBIA, 2006-2019
Intro: In 2010, PCV10 was introduced in the Colombian National Immunization Program (NIP) for children, with good vaccination coverage >82% since 2012. However, the NIP does not include routine pneumococcal vaccination for older adults. We assessed trends in mortality rate (MR) due to potential p...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223005957 |
| _version_ | 1797745240536252416 |
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| author | C. Parellada L.F. Reyes C. Beltran M. Rojas C. Zampirolli A. Abreu P. Pungartnik J.C. Orengo F. De La Hoz |
| author_facet | C. Parellada L.F. Reyes C. Beltran M. Rojas C. Zampirolli A. Abreu P. Pungartnik J.C. Orengo F. De La Hoz |
| author_sort | C. Parellada |
| collection | DOAJ |
| description | Intro: In 2010, PCV10 was introduced in the Colombian National Immunization Program (NIP) for children, with good vaccination coverage >82% since 2012. However, the NIP does not include routine pneumococcal vaccination for older adults. We assessed trends in mortality rate (MR) due to potential pneumococcal pneumonia (PPP) from 2006-2019. Methods: This ecological time-series study used Colombian nationwide administrative databases. We analyzed the pre-PCV10 (2006-2009) and post-PCV10 (2012-2019) periods, excluding the years 2010 and 2011 (transition period). ICD-10 codes included J13-J18. MRs were calculated per 100,000 people and stratified by age groups (<1, 1-4, 5-17, 18-49, 50-59, 60-64 and ≥65 years). The percent of change was calculated by the difference between the average rate in the pre-PCV and post-PCV periods for each age group. Joinpoint regression analysis was performed to assess changes in MRs. Annual percent changes (APCs) for each line segment and average APC (AAPC) over 2006-2019 were estimated. Findings: During 2006-2019, there were 102,082 deaths due to PPP. The highest MRs were seen for the age groups <1 and ≥65 years. Mean MRs decreased in age groups <18 years in the post-PCV10 period. A decreasing trend was seen primarily in those <1 year (AAPC -6.8; 95%CI: -8.6;-5.1) and 1-4 years (AAPC -5.0; 95%CI: -7.2;-2.8%) from 2006-2019. In contrast, for the age groups 50-59 years and 60-64 years, there was a significant increasing trend (AAPC 1.6%;95%CI 1.7%-5.1% and AAPC 3.4; 95%CI: 1.7;5.1, respectively) from 2006-2019. In ≥65 years, there was a significant increasing trend from 2011-2016 (APC 6.6; 95% CI: 0.5;13.1), followed by a non-significative decrease trend from 2016-2019 (APC -2.8; 95%CI-10.4;5.5). Conclusion: This study provided additional evidence for the benefits of childhood PCV programs. For older adults, MR has been consistently higher in post-vaccination period compared to pre-vaccination. These findings can inform decision-makers about the needs for pneumococcal vaccination among older adults in Colombia. |
| first_indexed | 2024-03-12T15:21:30Z |
| format | Article |
| id | doaj.art-21e209c1d2b54e6387bb6531627fd926 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-12T15:21:30Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-21e209c1d2b54e6387bb6531627fd9262023-08-11T05:32:16ZengElsevierInternational Journal of Infectious Diseases1201-97122023-08-01134S10TRENDS IN MORTALITY OF POTENTIAL PNEUMOCOCCAL PNEUMONIA IN COLOMBIA, 2006-2019C. Parellada0L.F. Reyes1C. Beltran2M. Rojas3C. Zampirolli4A. Abreu5P. Pungartnik6J.C. Orengo7F. De La Hoz8MSD Brazil, Outcomes Research, São Paulo, BrazilUniversidad de la Sabana, Clínica Universidad de La Sabana, Chía, ColombiaMSD Colombia, Scientific and Medical Affairs, Bogota, ColombiaMSD Colombia, Scientific and Medical Affairs, Bogota, ColombiaIQVIA, Real-World Insights, São Paulo, BrazilIQVIA, Real-World Insights, São Paulo, BrazilIQVIA, Real-World Insights, São Paulo, BrazilMSD (IA) LLC, Outcomes Research, Guaynabo, Puerto RicoUniversidad Nacional de Colombia, Public Health, Bogota, ColombiaIntro: In 2010, PCV10 was introduced in the Colombian National Immunization Program (NIP) for children, with good vaccination coverage >82% since 2012. However, the NIP does not include routine pneumococcal vaccination for older adults. We assessed trends in mortality rate (MR) due to potential pneumococcal pneumonia (PPP) from 2006-2019. Methods: This ecological time-series study used Colombian nationwide administrative databases. We analyzed the pre-PCV10 (2006-2009) and post-PCV10 (2012-2019) periods, excluding the years 2010 and 2011 (transition period). ICD-10 codes included J13-J18. MRs were calculated per 100,000 people and stratified by age groups (<1, 1-4, 5-17, 18-49, 50-59, 60-64 and ≥65 years). The percent of change was calculated by the difference between the average rate in the pre-PCV and post-PCV periods for each age group. Joinpoint regression analysis was performed to assess changes in MRs. Annual percent changes (APCs) for each line segment and average APC (AAPC) over 2006-2019 were estimated. Findings: During 2006-2019, there were 102,082 deaths due to PPP. The highest MRs were seen for the age groups <1 and ≥65 years. Mean MRs decreased in age groups <18 years in the post-PCV10 period. A decreasing trend was seen primarily in those <1 year (AAPC -6.8; 95%CI: -8.6;-5.1) and 1-4 years (AAPC -5.0; 95%CI: -7.2;-2.8%) from 2006-2019. In contrast, for the age groups 50-59 years and 60-64 years, there was a significant increasing trend (AAPC 1.6%;95%CI 1.7%-5.1% and AAPC 3.4; 95%CI: 1.7;5.1, respectively) from 2006-2019. In ≥65 years, there was a significant increasing trend from 2011-2016 (APC 6.6; 95% CI: 0.5;13.1), followed by a non-significative decrease trend from 2016-2019 (APC -2.8; 95%CI-10.4;5.5). Conclusion: This study provided additional evidence for the benefits of childhood PCV programs. For older adults, MR has been consistently higher in post-vaccination period compared to pre-vaccination. These findings can inform decision-makers about the needs for pneumococcal vaccination among older adults in Colombia.http://www.sciencedirect.com/science/article/pii/S1201971223005957 |
| spellingShingle | C. Parellada L.F. Reyes C. Beltran M. Rojas C. Zampirolli A. Abreu P. Pungartnik J.C. Orengo F. De La Hoz TRENDS IN MORTALITY OF POTENTIAL PNEUMOCOCCAL PNEUMONIA IN COLOMBIA, 2006-2019 International Journal of Infectious Diseases |
| title | TRENDS IN MORTALITY OF POTENTIAL PNEUMOCOCCAL PNEUMONIA IN COLOMBIA, 2006-2019 |
| title_full | TRENDS IN MORTALITY OF POTENTIAL PNEUMOCOCCAL PNEUMONIA IN COLOMBIA, 2006-2019 |
| title_fullStr | TRENDS IN MORTALITY OF POTENTIAL PNEUMOCOCCAL PNEUMONIA IN COLOMBIA, 2006-2019 |
| title_full_unstemmed | TRENDS IN MORTALITY OF POTENTIAL PNEUMOCOCCAL PNEUMONIA IN COLOMBIA, 2006-2019 |
| title_short | TRENDS IN MORTALITY OF POTENTIAL PNEUMOCOCCAL PNEUMONIA IN COLOMBIA, 2006-2019 |
| title_sort | trends in mortality of potential pneumococcal pneumonia in colombia 2006 2019 |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223005957 |
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