1,2,3-Triazoles as Biomimetics in Peptide Science
Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo. To overcome this limitation, the development of new molecules mimicking peptide...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/10/2937 |
| _version_ | 1827692471053713408 |
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| author | Naima Agouram El Mestafa El Hadrami Abdeslem Bentama |
| author_facet | Naima Agouram El Mestafa El Hadrami Abdeslem Bentama |
| author_sort | Naima Agouram |
| collection | DOAJ |
| description | Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo. To overcome this limitation, the development of new molecules mimicking peptides is of great importance for the development of new biologically active molecules. Therefore, replacing the amide bond in a peptide with a heterocyclic bioisostere, such as the 1,2,3-triazole ring, can be considered an effective solution for the synthesis of biologically relevant peptidomimetics. These 1,2,3-triazoles may have an interesting biological activity, because they behave as rigid link units, which can mimic the electronic properties of amide bonds and show bioisosteric effects. Additionally, triazole can be used as a linker moiety to link peptides to other functional groups. |
| first_indexed | 2024-03-10T11:23:38Z |
| format | Article |
| id | doaj.art-21e584116a54428997399af62f23f25f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:23:38Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-21e584116a54428997399af62f23f25f2023-11-21T19:50:38ZengMDPI AGMolecules1420-30492021-05-012610293710.3390/molecules261029371,2,3-Triazoles as Biomimetics in Peptide ScienceNaima Agouram0El Mestafa El Hadrami1Abdeslem Bentama2Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohammed Ben Abdellah University, Immouzer Road, Fez 30050, MoroccoLaboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohammed Ben Abdellah University, Immouzer Road, Fez 30050, MoroccoLaboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohammed Ben Abdellah University, Immouzer Road, Fez 30050, MoroccoNatural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo. To overcome this limitation, the development of new molecules mimicking peptides is of great importance for the development of new biologically active molecules. Therefore, replacing the amide bond in a peptide with a heterocyclic bioisostere, such as the 1,2,3-triazole ring, can be considered an effective solution for the synthesis of biologically relevant peptidomimetics. These 1,2,3-triazoles may have an interesting biological activity, because they behave as rigid link units, which can mimic the electronic properties of amide bonds and show bioisosteric effects. Additionally, triazole can be used as a linker moiety to link peptides to other functional groups.https://www.mdpi.com/1420-3049/26/10/29371,2,3-triazolepeptidomimeticCuAACamide bondclick chemistrybioisostere |
| spellingShingle | Naima Agouram El Mestafa El Hadrami Abdeslem Bentama 1,2,3-Triazoles as Biomimetics in Peptide Science Molecules 1,2,3-triazole peptidomimetic CuAAC amide bond click chemistry bioisostere |
| title | 1,2,3-Triazoles as Biomimetics in Peptide Science |
| title_full | 1,2,3-Triazoles as Biomimetics in Peptide Science |
| title_fullStr | 1,2,3-Triazoles as Biomimetics in Peptide Science |
| title_full_unstemmed | 1,2,3-Triazoles as Biomimetics in Peptide Science |
| title_short | 1,2,3-Triazoles as Biomimetics in Peptide Science |
| title_sort | 1 2 3 triazoles as biomimetics in peptide science |
| topic | 1,2,3-triazole peptidomimetic CuAAC amide bond click chemistry bioisostere |
| url | https://www.mdpi.com/1420-3049/26/10/2937 |
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