Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

Serum Response Factor (SRF) fulfills essential roles in post-natal retinal angiogenesis and adult neovascularization. These functions have been attributed to the recruitment by SRF of the cofactors Myocardin-Related Transcription Factors MRTF-A and -B, but not the Ternary Complex Factors (TCFs) Elk1...

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Main Authors: Christine Weinl, Christine Wasylyk, Marina Garcia Garrido, Vithiyanjali Sothilingam, Susanne C Beck, Heidemarie Riehle, Christine Stritt, Michel J Roux, Mathias W Seeliger, Bohdan Wasylyk, Alfred Nordheim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4159304?pdf=render

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http://europepmc.org/articles/PMC4159304?pdf=render

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