Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic Patients
Background: Diabetes mellitus is one of the commonest chronic disorders worldwide with a rapid rise in prevalence. In Iraq its prevalence is high especially in elderly age group. Patients with type 2 diabetes mellitus have higher vulnerability for complications, whether microvascular or macrovascul...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2022-05-01
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| Series: | مجله كليه طب الكندي |
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| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/799 |
| _version_ | 1798002065797021696 |
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| author | Muhannad Ghazi AnNasseh Saif Ibrahim Raheem Giyathaldeen Neamah |
| author_facet | Muhannad Ghazi AnNasseh Saif Ibrahim Raheem Giyathaldeen Neamah |
| author_sort | Muhannad Ghazi AnNasseh |
| collection | DOAJ |
| description |
Background: Diabetes mellitus is one of the commonest chronic disorders worldwide with a rapid rise in prevalence. In Iraq its prevalence is high especially in elderly age group. Patients with type 2 diabetes mellitus have higher vulnerability for complications, whether microvascular or macrovascular. Ocular complications are common in diabetes mellitus, and comprise diabetic retinopathy, diabetic papillopathy, cataract, glaucoma, dry eye disease and diabetic keratopathy. Diabetic keratopathy involves endothelial and epithelial tissues of the cornea, leading to persistent epithelial defect, corneal erosion, or corneal ulcers.
Aim of the Study: To compare the mean corneal endothelial cell count between patients with type 2 diabetes mellitus and non-diabetics.
Subjects and Methods: This is a case-control study conducted in Ibn Al Haitham Teaching Eye Hospital – Baghdad and included 249 participants, 125 cases with type 2 diabetes and 124 controls who had no diabetes. Endothelial cell count was measured for 1 eye of each participant using TOPCON® SP-3000P microscope. Patients who had diabetes for less than 5 years, and patients who had previous ocular surgery, injury or disorders were excluded.
Results: There was a significant difference in endothelial cell count between cases with type 2 diabetes mellitus and controls; P = 0.001. There was also a significant negative correlation between age and endothelial cell count, R = -0.20, P = 0.002. Similarly, there was a significant negative correlation between duration of diabetes mellitus and endothelial cell count, R = -0.44, P < 0.001.
Conclusions: Type 2 diabetes mellitus causes significant reduction in mean corneal endothelial cell count. There is also a negative correlation between corneal endothelial cell count and both age and duration of the disease.
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| first_indexed | 2024-04-11T11:46:16Z |
| format | Article |
| id | doaj.art-21e96f031bef4d36821745e75599d6e0 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-04-11T11:46:16Z |
| publishDate | 2022-05-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-21e96f031bef4d36821745e75599d6e02022-12-22T04:25:32ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652022-05-0118110.47723/kcmj.v18i1.799764Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic PatientsMuhannad Ghazi AnNasseh0Saif Ibrahim Raheem1Giyathaldeen Neamah2Ibn -Alhaitham Teaching Eye Hospital, Baghdad, Iraq Najaf teaching hospital, Najaf, Iraq Jabir Ibn Hayyan medical faculty Background: Diabetes mellitus is one of the commonest chronic disorders worldwide with a rapid rise in prevalence. In Iraq its prevalence is high especially in elderly age group. Patients with type 2 diabetes mellitus have higher vulnerability for complications, whether microvascular or macrovascular. Ocular complications are common in diabetes mellitus, and comprise diabetic retinopathy, diabetic papillopathy, cataract, glaucoma, dry eye disease and diabetic keratopathy. Diabetic keratopathy involves endothelial and epithelial tissues of the cornea, leading to persistent epithelial defect, corneal erosion, or corneal ulcers. Aim of the Study: To compare the mean corneal endothelial cell count between patients with type 2 diabetes mellitus and non-diabetics. Subjects and Methods: This is a case-control study conducted in Ibn Al Haitham Teaching Eye Hospital – Baghdad and included 249 participants, 125 cases with type 2 diabetes and 124 controls who had no diabetes. Endothelial cell count was measured for 1 eye of each participant using TOPCON® SP-3000P microscope. Patients who had diabetes for less than 5 years, and patients who had previous ocular surgery, injury or disorders were excluded. Results: There was a significant difference in endothelial cell count between cases with type 2 diabetes mellitus and controls; P = 0.001. There was also a significant negative correlation between age and endothelial cell count, R = -0.20, P = 0.002. Similarly, there was a significant negative correlation between duration of diabetes mellitus and endothelial cell count, R = -0.44, P < 0.001. Conclusions: Type 2 diabetes mellitus causes significant reduction in mean corneal endothelial cell count. There is also a negative correlation between corneal endothelial cell count and both age and duration of the disease. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/799diabetescorneal endotheliumspecular microscopy |
| spellingShingle | Muhannad Ghazi AnNasseh Saif Ibrahim Raheem Giyathaldeen Neamah Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic Patients مجله كليه طب الكندي diabetes corneal endothelium specular microscopy |
| title | Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic Patients |
| title_full | Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic Patients |
| title_fullStr | Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic Patients |
| title_full_unstemmed | Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic Patients |
| title_short | Comparative Study on the Corneal Endothelial Cell Count between Type 2 Diabetic and Non-Diabetic Patients |
| title_sort | comparative study on the corneal endothelial cell count between type 2 diabetic and non diabetic patients |
| topic | diabetes corneal endothelium specular microscopy |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/799 |
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